Nasopharyngeal carcinoma and the EBV-specific T cell response: prospects for immunotherapy
Nasopharyngeal carcinoma and the EBV-specific T cell response: prospects for immunotherapy
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DOI：
10.1016/s1044-579x(02)00089-5
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发表时间：
2002-12-01
影响因子：
14.5
通讯作者：
Lee, SP
中科院分区：
文献类型：
--
作者：
Lee, SP
EB病毒（EBV）特异性T细胞可以有效靶向免疫抑制移植患者中出现的病毒转化的B淋巴增生性病变。这篇综述探讨了开发类似的T细胞为基础的策略来治疗EBV阳性的上皮性肿瘤，鼻咽癌（NPC），这是在相对免疫能力强的个人和肿瘤中的EBV抗原表达更有限的可能性。
T cells specific for Epstein-Barr virus (EBV) can effectively target the virus-transformed B lymphoproliferative lesions that arise in immunosuppressed transplant patients. This review explores the possibility of developing similar T cell-based strategies to treat an EBV-positive epithelial tumour, nasopharyngeal carcinoma (NPC), which arises in relatively immunocompetent individuals and where EBV antigen expression in the tumour is more limited.