Brain trauma impacts retinal processing: photoreceptor pathway interactions in traumatic light sensitivity.
Brain trauma impacts retinal processing: photoreceptor pathway interactions in traumatic light sensitivity.
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DOI：
10.1007/s10633-022-09871-1
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发表时间：
2022-06
影响因子：
1.4
通讯作者：
Likova, Lora T.
中科院分区：
文献类型：
--
作者：
Tyler, Christopher W.;Likova, Lora T.
脑震荡引起的光敏感或创伤性光痛是超过50%的轻度创伤性脑损伤（mTBI）病例的终身衰弱问题，尽管病因不明。我们采用视网膜电图（ERG）反应的光谱分析来评估mTBI中视网膜的变化作为光痛程度的函数。该设计是一项病例对照研究，研究了轻度创伤性脑损伤患者的ERG波形变化与光敏感度水平的关系。mTBI参与者根据他们的光谱伤害物理设置分为非，轻度和重度光痛组。记录每只眼睛在200 ms三种光谱颜色（R：红色，G：绿色和B：蓝色）的开关刺激下的光适应ERG反应，以及每名参与者在最高无痛强度水平下的总和（W：白色）。通过记录对照组中的完整光强度系列，解决了在较低光水平下测试过敏个体的对照要求。与对照组相比，非光痛性mTBI组的b波和明视负反应（PhNR）均显著降低。在光痛组中，主b波峰值移动到杆b波的时间，在锥反应的时间降低幅度。这些结果表明，mTBI中疼痛性光敏感性的主要病因是在高光水平下视锥细胞介导的抑制释放视杆细胞通路，导致视杆细胞通路过度激活。
Concussion-induced light sensitivity, or traumatic photalgia, is a lifelong debilitating problem for upwards of 50% of mild traumatic brain injury (mTBI) cases, though of unknown etiology. We employed spectral analysis of electroretinographic (ERG) responses to assess retinal changes in mTBI as a function of the degree of photalgia. The design was a case–control study of the changes in the ERG waveform as a function of level of light sensitivity in individuals who had suffered incidents of mild traumatic brain injury. The mTBI participants were categorized into non-, mild-, and severe-photalgic groups based on their spectral nociophysical settings. Light-adapted ERG responses were recorded from each eye for 200 ms on–off stimulation of three spectral colors (R:red, G:green, and B:blue) and their sum (W:white) at the highest pain-free intensity level for each participant. The requirement of controls for testing hypersensitive individuals at lower light levels was addressed by recording a full light intensity series in the control group. Both the b-wave and the photopic negative response (PhNR) were significantly reduced in the non-photalgic mTBI group relative to controls. In the photalgic groups, the main b-wave peak shifted to the timing of the rod b-wave, with reduced amplitude at the timing of the cone response. These results suggest the interpretation that the primary etiology of the painful light sensitivity in mTBI is release of the rod pathway from cone-mediated inhibition at high light levels, causing overactivation of the rod pathway.
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影响因子：
1.4
作者：
Marmor, M. F.;Fulton, A. B.;Bach, M.
通讯作者：
Bach, M.
影响因子：
4.1
作者：
Michaelides, M;Holder, GE;Moore, AT
通讯作者：
Moore, AT
影响因子：
5.5
作者：
ADRIAN, ED
通讯作者：
ADRIAN, ED
DOI：
10.1007/bf02764303
发表时间：
1990-01-01
影响因子：
2.7
作者：
FOERSTER, MH;KELLNER, U;WESSING, A
通讯作者：
WESSING, A
影响因子：
4.4
作者：
Mohan, Kabhilan;Kecova, Helga;Harper, Matthew M.
通讯作者：
Harper, Matthew M.