High Expression of Delta-Like Ligand 4 Predicts Poor Prognosis After Curative Resection for Pancreatic Cancer
High Expression of Delta-Like Ligand 4 Predicts Poor Prognosis After Curative Resection for Pancreatic Cancer
复制标题
δ样配体4的高表达预示胰腺癌根治性切除后预后不良
DOI：
10.1245/s10434-011-1968-9
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发表时间：
2012-07-01
影响因子：
3.7
通讯作者：
Li, Zhao-Shen
中科院分区：
文献类型：
--
作者：
Chen, Hai-Tao;Cai, Quan-Cai;Li, Zhao-Shen
背景Delta-like ligand 4（DLL 4）-Notch信号在肿瘤血管生成中起关键作用，但其在胰腺导管腺癌（PDAC）患者中的预后价值仍不清楚。我们的目的是确定DLL 4高表达是否与PDAC根治性切除后的不良预后相关。方法.对89例PDAC患者的手术标本进行DLL 4和血管内皮生长因子受体2（VEGFR-2）表达的免疫组化评估。采用Kaplan-Meier法和考克斯回归分析评价DLL 4表达与预后的关系。采用卡方检验和多因素Logistic回归分析DLL 4表达与VEGFR-2表达、肿瘤分期和淋巴结转移的相关性。结果分别有38例（42.7%）和51例患者显示DLL 4高表达和低表达。生存曲线显示DLL 4低表达患者的生存率明显高于DLL 4高表达患者（P
Background. Delta-like ligand 4 (DLL4)-Notch signaling plays a key role in tumor angiogenesis, but its prognostic value in patients with pancreatic ductal adenocarcinoma (PDAC) remains unclear. Our aim was to determine whether high DLL4 expression is correlated with poor prognosis after curative resection for PDAC. Methods. Surgical specimens obtained from 89 patients with PDAC were immunohistochemically assessed for DLL4 and vascular endothelial growth factor receptor 2 (VEGFR-2) expression. Prognostic significance of DLL4 expression was evaluated by Kaplan-Meier method and Cox regression. The correlations of DLL4 expression with VEGFR-2 expression, tumor stage, and lymph node metastasis were examined by chi-square test and multivariate logistic regression. Results. There were 38 (42.7%) and 51 patients who showed high and low DLL4 expression, respectively. Survival curves showed that patients with low DLL4 expression had a significantly better survival than those with high DLL4 expression (P