Prevalence of Detectable C-Peptide According to Age at Diagnosis and Duration of Type 1 Diabetes
Prevalence of Detectable C-Peptide According to Age at Diagnosis and Duration of Type 1 Diabetes
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DOI：
10.2337/dc14-1952
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发表时间：
2015-03-01
期刊：
影响因子：
16.2
通讯作者：
Greenbaum, Carla J.
中科院分区：
文献类型：
--
作者：
Davis, Asa K.;DuBose, Stephanie N.;Greenbaum, Carla J.
一般认为，1型糖尿病患者最终会发生完全的β细胞破坏，这对治疗方法和保险范围都有影响。研究设计和方法通过测量919名1型糖尿病患者的非空腹血清C-肽浓度，根据诊断时的年龄和疾病持续时间，根据预先指定的组，确定残余胰岛素分泌的频率（任期3至81年）。刺激C肽在那些可检测的非空腹值和一组作为control. TSTSThe可检测的非空腹C肽的总频率为29%，随着时间的推移，从诊断降低，无论在诊断的年龄。在所有病程组中，诊断年龄>18岁的C肽频率高于诊断年龄>18岁的C肽频率。
OBJECTIVEIt is generally accepted that complete beta-cell destruction eventually occurs in individuals with type 1 diabetes, which has implications for treatment approaches and insurance coverage. The frequency of residual insulin secretion in a large cohort of individuals at varying ages of diagnosis and type 1 diabetes duration is unknown.RESEARCH DESIGN AND METHODSThe frequency of residual insulin secretion was determined by measurement of non-fasting serum C-peptide concentration in 919 individuals with type 1 diabetes according to prespecified groups based on age at diagnosis and duration of disease (from 3 to 81 years' duration). Stimulated C-peptide was measured in those with detectable nonfasting values and a group of those with undetectable values as control.RESULTSThe overall frequency of detectable nonfasting C-peptide was 29%, decreasing with time fromdiagnosis regardless of age at diagnosis. In all duration groups, the frequency of C-peptide was higher with diagnosis age >18 years compared with