Sister-chromatid exchanges.
Sister-chromatid exchanges.
复制标题
姐妹染色单体交换。
DOI：
10.1007/978-1-4615-8288-5_4
复制
发表时间：
1979
期刊：
影响因子：
3.3
通讯作者：
Charles F. Shuler
中科院分区：
文献类型：
--
作者：
Samuel A. Latt;Rhona Schreck;Kenneth S. Loveday;Charlotte P. Dougherty;Charles F. Shuler
姐妹染色单体交换（sce）是DNA复制产物在同源位点上的交换。这些交换可能涉及DNA断裂和团聚，尽管对姐妹染色单体交换形成的分子基础知之甚少，关于交换的生物学意义的信息在很大程度上是间接的。尽管存在这些不确定性，对细胞学系统中姐妹染色单体交换形成的分析已经提供了关于染色体结构的信息，并已被用于检测致裂原的影响和区分染色体易碎性疾病。
Sister chromatid exchanges (SCEs) represent the interchange of DNA replication products at apparently homologous loci. These exchanges presumably involve DNA breakage and reunion, although little is known about the molecular basis of sister chromatid exchange formation, and information about the biological significance of exchanges is largely circumstantial. In spite of these uncertainties, analysis of sister chromatid exchange formation in cytological systems has already provided information about chromosome structure and has been used to detect the effects of clastogens and to differentiate between chromosome fragility diseases.