JAK/STAT disruption induces immuno-deficiency: Rationale for the development of JAK inhibitors as immunosuppressive drugs
JAK/STAT disruption induces immuno-deficiency: Rationale for the development of JAK inhibitors as immunosuppressive drugs
复制标题
DOI：
10.1016/j.mce.2017.01.035
复制
发表时间：
2017-08-15
影响因子：
4.1
通讯作者：
Wolf, Dominik
中科院分区：
文献类型：
--
作者：
Cornez, Isabelle;Yajnanarayana, Sowmya Parampalli;Wolf, Dominik
细胞因子通过激活JAK/STAT信号通路介导免疫细胞应答。作为免疫细胞的关键，有缺陷的JAK/STAT信号转导导致各种免疫疾病，如免疫缺陷。相反，JAK/STAT信号的过度激活与自身免疫和癌症有关。通过小蛋白抑制剂靶向JAK/STAT蛋白，通过使细胞与细胞因子效应解偶联以及通过干扰功能性免疫细胞标志（例如细胞迁移）来阻碍免疫细胞功能。本文将探讨JAK/STAT失调驱动的免疫综合征，并讨论在自身免疫和移植医学中使用的免疫抑制剂的新作用。(C)2017爱思唯尔B. V.保留所有权利。
Cytokines are mediating immune cells responses through the activation of the JAK/STAT signaling pathway. Being critical for immune cells, a defective JAK/STAT signaling leads to various immune disorders, such as immunodeficiency. In contrast, hyperactivation of JAK/STAT signaling is linked to auto immunity and cancer. Targeting the JAK/STAT proteins by small protein inhibitors impedes immune cell function by uncoupling cells from cytokine effects and by interfering with functional immune cell hallmarks, such as cell migration. This review will explore immune syndromes driven by JAK/STAT deregulation and discuss the emerging role of JAR inhibitors as immunosuppressive drugs used in autoimmunity and transplantation medicine. (C) 2017 Elsevier B.V. All rights reserved.