The hOGG1 Ser326Cys polymorphism and lung cancer risk:: A meta-analysis
The hOGG1 Ser326Cys polymorphism and lung cancer risk:: A meta-analysis
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DOI：
10.1158/1055-9965.epi-08-0001
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发表时间：
2008-07-01
影响因子：
3.8
通讯作者：
Chen, Kexin
中科院分区：
文献类型：
--
作者：
Li, Haixin;Hao, Xishan;Chen, Kexin
人类8-氧鸟嘌呤DNA糖基化酶（hOGG1）基因中潜在的功能多态性Ser326Cys与肺癌风险有关，但已发表的研究结果好坏参半。为了总结已发表的数据，我们进行了全面的荟萃分析。两位研究者使用搜索短语“hOGG1/OGG1/OGG和多态性/遗传变异与肺癌”，从PubMed上发表的17例病例对照研究中独立提取数据。荟萃分析包括6375例癌症病例和6406名对照受试者。结果显示，携带hOGG1 Cys/Cys基因型的个体患肺癌的风险没有显著增加[比值比（OR）， 1.15；95%（置信区间）CI, 0.94-1.41]，与Ser/Ser基因型比较；同样，在隐性模式（OR, 1.09; 95% CI， Cys/Cys与Ser/Cys+Ser/Ser）或显性模式（OR, 1.06; 95% cl, 0.93-1.21， Cys/Cys+Ser/Cys与Ser/Ser）中均未发现与肺癌风险有显著关联。然而，在显性模型中，亚洲受试者的风险显著增加（OR为1.18；Cys/Cys+Ser/Cys与Ser/Ser相比，95% Cl为1.01-1.38）。在对照源的分层分析中，与Ser/Ser基因型相比，基于人群的研究中与hOGG1 Cys/Cys基因型相关的肺癌风险显著增加（OR, 1.32; 93% CI, 1.04-1.67），但在基于医院的研究中没有（OR, 1.18; 95% CI, 0.98-1.42）；然而，在吸烟状况的分层分析中，在优势模型中仅在非吸烟者中观察到风险增加（OR, 1.32; 95% Cl, 1.04-1.67）。荟萃分析表明，在未来包括多种族群体的更大的遗传关联研究中，应考虑仔细匹配。
The potentially functional polymorphism Ser326Cys in the human 8-oxoguanine DNA glycosylase (hOGG1) gene has been implicated in lung cancer risk, but published studies have mixed findings. To summarize published data, we did a comprehensive meta-analysis. Two investigators extracted data independently from 17 case control studies published in the PubMed using the search phrases "hOGG1/OGG1/OGG and polymorphism/genetic variation and lung cancer." The meta-analysis included 6,375 cancer cases and 6,406 control subjects. The results showed that individuals carrying the hOGG1 Cys/Cys genotype did not have significantly increased risk of lung cancer [odds ratios (OR), 1.15; 95% (confidence interval) CI, 0.94-1.41] compared with those with the Ser/Ser genotype; similarly, no significant association with lung cancer risk was found either in the recessive (OR, 1.09; 95% CI, 0.90-1.32 for Cys/Cys versus Ser/Cys+Ser/Ser) or dominant model of the Ser326 allele (OR, 1.06; 95% cl, 0.93-1.21 for Cys/Cys+Ser/Cys versus Ser/Ser). However, significantly increased risks were found among Asian subjects (OR, 1.18; 95% Cl, 1.01-1.38 for Cys/Cys+Ser/Cys versus Ser/Ser) in a dominant model. In stratified analyses by control source, compared with the Ser/Ser genotype, lung cancer risk associated with the hOGG1 Cys/Cys genotype was significantly increased in population-based studies (OR, 1.32; 93% CI, 1.04-1.67) but not in hospital-based studies (OR, 1.18; 95% CI, 0.98-1.42); in stratified analyses by the smoking status, however, the increased risk was observed only among nonsmokers in a dominant model (OR, 1.32; 95% Cl, 1.04-1.67). The meta-analysis suggested that a careful matching should be considered in future larger genetic association studies including multiple ethnic groups.