Morphology Control of Trimer Particles via One-step Co-Precipitation and Controlled Phase Separation
Morphology Control of Trimer Particles via One-step Co-Precipitation and Controlled Phase Separation
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DOI：
10.1016/j.ces.2022.117432
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发表时间：
2022-01
影响因子：
4.7
通讯作者：
Li Chen;Jinyi Chen;Zhu Sun;Baiheng Wu;Fangfu Ye;Chunlan Zhao;Dong Chen
中科院分区：
文献类型：
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作者：
Li Chen;Jinyi Chen;Zhu Sun;Baiheng Wu;Fangfu Ye;Chunlan Zhao;Dong Chen
纳米沉淀法是制备生物相容性纳米粒子的一种灵活的方法，可用于药物递送等。然而，由于多种聚合物的溶解度不同，通常很难共沉淀。本文首次采用快速溶剂交换和控制相分离的一步共沉淀法制备了紫胶/PLA/PS三聚体NPs。紫胶/PLA/PS NPs的形貌与不同相之间的界面张力密切相关，并且可以通过在连续水相中加入分子表面活性剂来调节。由于共沉淀是一个快速的过程，因此系统达到热平衡状态的首选温度较高；否则，系统可能在动力学上被锁定在中间状态。本文还详细研究了聚合物分子量和界面张力的影响，揭示了制备具有线性或三角形结构的紫胶/PLA/PS三聚体NPs的潜在机制。本研究将为一步共沉淀法和控制相分离法设计和制备组分更多样化、结构更复杂的NPs提供新的思路，并进一步拓展NPs的潜在应用领域。
Nanoprecipitation is a flexible method to prepare biocompatible nanoparticles (NPs) for drug delivery and so on. However, it is generally hard to co-precipitate multiple polymers due to their different solvent solubility. Here, shellac/PLA/PS trimer NPs are prepared for the first time via one-step co-precipitation upon rapid solvent exchange and controlled phase separation. The morphology of shellac/PLA/PS NPs strongly depends on the interfacial tensions between different phases and could be tuned by the molecular surfactant added in the continuous aqueous phase. Since co-precipitation is a fast process, a high temperature is preferred for the system to reach the thermal equilibrium state; otherwise, the system may kinetically be locked in an intermediate state. The influences of polymer molecular weight and interfacial tension are also investigated in detail to reveal the underlying mechanisms of preparing shellac/PLA/PS trimer NPs with linear or triangular structures. This study will shield new light on the design and preparation of NPs with more diverse compositions and more complex structures via one-step co-precipitation and controlled phase separation and further expand the potential applications of NPs.