The dysfunction of inhibition control in pituitary patients: evidence from the Go/Nogo event-related potential study
The dysfunction of inhibition control in pituitary patients: evidence from the Go/Nogo event-related potential study
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垂体患者的抑制控制功能障碍：Go/Nogo 事件相关电位研究的证据
DOI：
10.1097/wnr.0000000000000757
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发表时间：
2017-03-22
期刊：
影响因子：
1.7
通讯作者：
Xu, Guozheng
中科院分区：
文献类型：
--
作者：
Cao, Chenglong;Song, Jian;Xu, Guozheng
垂体瘤是一种颅内肿瘤，由于近年来神经影像技术的发展，发病率有可能增加。有证据表明，垂体腺瘤患者的认知能力受损。有证据表明，神经行为障碍在垂体腺瘤患者中很常见。这种紊乱是由于大脑重要功能区的认知和情感功能受压和荷尔蒙失衡所致。个体的精神活动是由大脑控制的，而精神活动的异常是由大脑的结构异常和神经化学功能障碍共同引起的。事件相关电位已被广泛应用于疾病相关认知功能的早期评估，利用高时间分辨率，从认知加工的角度分析情绪能力的特征。使用了视觉GO/NOGO任务。对照组Nogo-N2和Nogo-P3均大于垂体组。这反映了脑垂体病患者冲突监测和抑制性控制的非生理学过程。与垂体组相比，对照组前额叶电极上GO和Nogo状态的差异波(N2d和P3d)更强健且更早，这反映了垂体组的额叶功能障碍。这些数据表明，垂体个体抑制过程的早期和后期减少，暗示了冲突检测和抑制控制的功能障碍。
Pituitary tumor is an intracranial tumor; because of the development of neuroimaging technology in recent years, morbidity is likely to increase. Evidence showed impaired cognitive ability of patients with pituitary adenoma. There is evidence that neurobehavioral disorders are common in pituitary adenoma patients. This disorder is because of the cognitive and emotional function of the important functional areas of the brain oppressed and hormone imbalance. Individuals’ mental activity is controlled by the brain and the abnormal mental activity is caused by both the structural abnormalities of the brain and neurochemical dysfunction. Event-related potentials have been used widely in the early assessment of cognitive functions associated with disease, taking advantage of the high temporal resolution, and then analyzing the characteristics of emotional competence from the perspective of cognitive processing. A visual Go/Nogo task was used. A larger Nogo-N2 and Nogo-P3 was found in the control group compared with the pituitary group. This reflects the nonphysiological process of conflict monitoring and inhibitory control in pituitary patients. The results also showed that the difference waves between Go and Nogo conditions (N2d and P3d) over the frontal electrode sites were more robust and earlier in the control group compared with the pituitary group, which reflects frontal dysfunction in the pituitary group. These data suggest reduced earlier and later stages of inhibitory processes in pituitary individuals, implicating the dysfunction of conflict detection and inhibitory control.