Methodology of drug screening and target identification for new necroptosis inhibitors
Methodology of drug screening and target identification for new necroptosis inhibitors
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新型坏死性凋亡抑制剂的药物筛选和靶点鉴定方法学
DOI：
10.1016/j.jpha.2018.11.002
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发表时间：
2018
影响因子：
8.8
通讯作者：
Yifeng Chai
中科院分区：
文献类型：
--
作者：
PengChao Pan;ZhenYu Cai;ChunLin Zhuang;Xiaofei Chen;Yifeng Chai
长期以来，细胞凋亡一直被认为是调节细胞死亡的唯一形式。然而，最近报道了一种新的细胞程序性死亡形式，称为坏死性下垂。坏死性下垂的过程是受调节的，在多种人类疾病的发生和发展中起着关键作用。因此，对坏死性上睑下垂的分子机制及其有效抑制剂的研究一直是研究者关注的领域。本文介绍了坏死性下垂的分子机制，并对近年来有关坏死性下垂药物筛选的文献进行了综述。此外，还对坏死性下垂的关键药物靶点的确定进行了讨论。
Apoptosis has been considered as the only form of regulated cell death for a long time. However, a novel form of programmed cell death called necroptosis was recently reported. The process of necroptosis is regulated and plays a critical role in the occurrence and development of multiple human diseases. Thus, the study on the molecular mechanism of necroptosis and its effective inhibitors has been an attractive field for researchers. Herein, we introduce the molecular mechanism of necroptosis and focus on the literature about necroptosis drug screening in recent years. In addition, the identification of the critical drug targets of the necroptosis is also discussed.