Nitric oxide signalling in the regulation of cardiovascular and platelet function
Nitric oxide signalling in the regulation of cardiovascular and platelet function
复制标题
DOI：
10.2741/3828
复制
发表时间：
2011-01-01
影响因子：
3.1
通讯作者：
Ferro, Albert
中科院分区：
文献类型：
--
作者：
Gkaliagkousi, Eugenia;Ferro, Albert
一氧化氮（NO）对心血管系统具有重要的保护作用。通过内皮（或3型）一氧化氮合酶（NOS 3）的作用由L-精氨酸产生，NO调节人体血管张力并引起内皮依赖性血管舒张。此外，内皮源性NO发挥抗氧化、抗增殖和抗炎特性，因此在抑制动脉粥样硬化过程中起重要作用。关于对血小板功能的影响，由内皮细胞和血小板产生的NO通过降低血小板活化而具有重要的抗血栓形成作用，血小板活化是一种对伴随各种心血管疾病状态的血栓形成倾向有重要贡献的现象。此外，通过抑制血小板活化，NO防止血小板和单核细胞之间的异型聚集，从而减少循环中的单核细胞-血小板聚集体，其被认为在动脉粥样硬化的起始和进展中起重要的病理生理作用。新的治疗干预措施，旨在提高NO的可用性已在动物以及体外研究中进行了研究，并显示出相当大的希望，但它仍有待观察，这种疗法是否将在人类临床上同样有效。
Nitric oxide (NO) exerts important protective actions on the cardiovascular system. Generated from L-arginine by the action of endothelial (or type 3) nitric oxide synthase (NOS3), NO regulates vascular tone in humans and causes endothelium-dependent vasodilation. Additionally endothelium-derived NO exerts antioxidant, antiproliferative and anti-inflammatory properties, thus playing an important role in inhibiting the atherosclerotic process. With regard to effects on platelet function, NO produced by both endothelial cells and platelets has important antithrombotic effects by decreasing platelet activation, a phenomenon which contributes importantly to the thrombotic tendency which accompanies a variety of cardiovascular disease states. Additionally, by inhibiting platelet activation, NO prevents heterotypic aggregation between platelets and monocytes, thereby reducing monocyte-platelet aggregates in the circulation which are believed to play an important pathophysiological role in the initiation and progression of atherosclerosis. New therapeutic interventions aimed at improving NO availability have been investigated in animal as well as in vitro studies and show considerable promise, but it remains to be seen whether such therapies will be equally efficacious in humans clinically.