Effects of pair bonding on dopamine D1 receptors in monogamous male titi monkeys (Callicebus cupreus)
Effects of pair bonding on dopamine D1 receptors in monogamous male titi monkeys (Callicebus cupreus)
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DOI：
10.1002/ajp.22612
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发表时间：
2017-03-01
影响因子：
2.4
通讯作者：
Bales, Karen L.
中科院分区：
文献类型：
--
作者：
Hostetler, Caroline M.;Hinde, Katherine;Bales, Karen L.
配对结合导致单配偶草原田鼠伏隔核多巴胺D1受体（D1R）结合增加。在目前的研究中，我们假设在一夫一妻制的灵长类动物——山雀猴（Callicebus cupreus）中也存在类似的D1R上调。在雄性山猴与雌性配对前后，使用PET扫描测量了D1R拮抗剂[C-11]-SCH23390的受体结合。我们发现配对的受试者内部分析显示，侧隔的D1R结合显著增加，但伏隔核、尾状核、壳核或腹侧白球核没有增加。侧隔参与了许多可能影响社会行为的过程，包括动机、情感、奖励和强化。这个区域在田鼠的配对和父系行为中也起作用。我们对侧隔D1R变化的观察，而不是伏隔核的观察，表明在哺乳动物物种的配对中可能存在大致相似的多巴胺能机制，但神经回路的具体变化不同。这项研究首次证明了非人类灵长类动物配对后多巴胺系统的神经可塑性；然而，对配对反应的实质性变化表明对该主题进行进一步研究的实用性。
Pair bonding leads to increases in dopamine D1 receptor (D1R) binding in the nucleus accumbens of monogamous prairie voles. In the current study, we hypothesized that there is similar up-regulation of D1R in a monogamous primate, the titi monkey (Callicebus cupreus). Receptor binding of the D1R antagonist [C-11]-SCH23390 was measured in male titi monkeys using PET scans before and after pairing with a female. We found that within-subject analyses of pairing show significant increases in D1R binding in the lateral septum, but not the nucleus accumbens, caudate, putamen, or ventral pallidum. The lateral septum is involved in a number of processes that may contribute to social behavior, including motivation, affect, reward, and reinforcement. This region also plays a role in pair bonding and paternal behavior in voles. Our observations of changes in D1R in the lateral septum, but not the nucleus accumbens, suggest that there may be broadly similar dopaminergic mechanisms underlying pair bonding across mammalian species, but that the specific changes to neural circuitry differ. This study is the first research to demonstrate neuroplasticity of the dopamine system following pair bonding in a non-human primate; however, substantial variability in the response to pairing suggests the utility of further research on the topic.