Effects of Negative Affect, Urge to Smoke, and Working Memory Performance (n-back) on Nicotine Dependence.
Effects of Negative Affect, Urge to Smoke, and Working Memory Performance (n-back) on Nicotine Dependence.
复制标题
负面情绪、吸烟冲动和工作记忆表现（n-back）对尼古丁依赖的影响。
DOI：
10.1080/10826084.2017.1400569
复制
发表时间：
2018
影响因子：
2
通讯作者：
Abrantes,AnaM
中科院分区：
文献类型：
--
作者：
Lechner,WilliamV;LGunn,Rachel;Minto,Alexia;Philip,NoahS;Brown,RichardA;Uebelacker,LisaA;Price,LawrenceH;Abrantes,AnaM
背景：负面情绪、激励显着性和执行功能三个关键领域构成了成瘾行为的核心功能要素。与这些更广泛领域相关的变量之间的相互关系已得到广泛研究；然而，迄今为止，还没有研究检验包含与尼古丁依赖相关的所有三个领域的变量的模型。方法：吸烟者（N = 117），65.8% 女性，78% 白人，平均年龄 44.4 岁（SD = 10.8），参加戒烟计划，完成负面影响（负面情绪的组成部分）、吸烟冲动（激励显着性）和工作记忆（WM；核心执行力）的测量功能），在开始治疗之前的基线评估期间。结果：负面情绪与更大的吸烟冲动相关，而这种吸烟冲动的增加与更高水平的尼古丁依赖相关。此外，显着的调节中介表明，WM 调节了吸烟冲动增加与尼古丁依赖之间的关系。对于那些 WM 较低至平均水平的人来说，吸烟的冲动与尼古丁依赖显着相关。然而，对于那些 WM 较高（+1 SD）的人来说，由于负面情绪而产生的吸烟冲动与尼古丁依赖无关。结论：据我们所知，这是第一个报道的负面情绪、吸烟冲动、WM 和尼古丁依赖之间的关系。尽管是初步结果，但结果表明，WM 可能会调节与负面情绪相关的吸烟冲动与尼古丁依赖之间的关系。针对 WM 的治疗可能对于具有平均至低 WM 且经历与负面情绪相关的吸烟冲动的个体特别有用。
Background: Three key domains including negative emotionality, incentive salience, and executive function form the core functional elements of addictive behaviors. Variables related to these broader domains have been studied extensively in relation to one another; however, no studies to date, have examined models including variables from all three domains, in relation to nicotine dependence.Method: Smokers (N= 117), 65.8% female, 78% white, mean age of 44.4 (SD = 10.8), enrolled in a smoking cessation program completed measures of negative affect (a component of negative emotionality), urge to smoke (incentive salience), and working memory (WM; a core executive function), during a baseline assessment period prior to initiating treatment.Results: Negative affect was associated with greater urge to smoke, and this elevated urge to smoke was associated with higher levels of nicotine dependence. Further, a significant moderated mediation indicated that WM moderated the relationship between increased urge to smoke and nicotine dependence. For those with low to average WM, urge to smoke was significantly related to nicotine dependence; however, for those with higher WM (+1 SD), urge to smoke stemming from negative affect was not associated with nicotine dependence.Conclusions: To our knowledge, this is the first reported relationship between negative affect, urge to smoke, WM, and nicotine dependence. Although preliminary, results indicate that WM may moderate the relationship between urge to smoke associated with negative affect and nicotine dependence. Treatments targeting WM may be particularly useful for individuals with average to low WM who experience urge to smoke related to negative affect.