Fatty acid synthase expression in cutaneous melanocytic neoplasms
Fatty acid synthase expression in cutaneous melanocytic neoplasms
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DOI：
10.1038/modpathol.3800395
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发表时间：
2005-08-01
期刊：
影响因子：
7.5
通讯作者：
Hoang, MP
中科院分区：
文献类型：
--
作者：
Kapur, P;Rakheja, D;Hoang, MP
哺乳动物脂肪酸合成酶是一种参与饱和脂肪酸从头合成的多功能酶复合物，脂肪酸合成酶抑制剂正被评估为潜在的治疗剂。脂肪酸合酶表达增加已在恶性肿瘤亚群中得到证实，包括结肠癌、乳腺癌、子宫内膜癌、前列腺癌和卵巢癌，以及最近的恶性黑色素瘤。我们评估了155例皮肤黑素细胞病变中脂肪酸合成酶的免疫组化表达。其中先天性痣30例，复合痣19例，Spitz痣40例，原发性黑色素瘤48例，转移性黑色素瘤18例。脂肪酸合成酶的表达在恶性黑色素瘤中比常规痣和Spitz痣更强，并且在转移性黑色素瘤中表达最高。在原发性恶性黑色素瘤中，Clark IV级和V级的平均脂肪酸合成酶评分显著高于Clark I级和II级（P <1.50 mm），平均脂肪酸合成酶评分显著高于Breslow厚度
Mammalian fatty acid synthase is a multifunctional enzyme complex involved in de novo synthesis of saturated fatty acids, and inhibitors of fatty acid synthase are being evaluated as potential therapeutic agents. Increased fatty acid synthase expression has been demonstrated in subsets of malignancies, including colon, breast, endometrium, prostate and ovarian carcinomas, and recently malignant melanomas. We evaluated the immunohistochemical expression of fatty acid synthase in 155 cutaneous melanocytic lesions. They included 30 congenital nevi, 19 compound nevi, 40 Spitz nevi, 48 primary melanomas, and 18 metastatic melanomas. Fatty acid synthase expression was stronger in malignant melanomas in comparison to conventional nevi and Spitz nevi, and was the highest for metastatic melanoma. Of the primary malignant melanomas, mean fatty acid synthase scores were significantly greater for Clark levels IV and V compared to Clark levels I and II (P1.50 mm showed significantly higher mean fatty acid synthase scores compared with those with Breslow thickness