THE T-CELL REPERTOIRE MAY BE BIASED IN FAVOR OF MHC RECOGNITION
THE T-CELL REPERTOIRE MAY BE BIASED IN FAVOR OF MHC RECOGNITION
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DOI：
10.1016/0092-8674(86)90591-x
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发表时间：
1986-11-07
期刊：
影响因子：
64.5
通讯作者：
MARRACK, P
中科院分区：
文献类型：
--
作者：
BLACKMAN, M;YAGUE, J;MARRACK, P
比较了分别识别 I 类和 II 类主要组织相容性复合体 (MHC) 分子的两种 T 细胞杂交瘤的受体。在这两种情况下，这些受体都是由于细胞融合而形成的杂合分子。这些受体含有相同的α。链，由肿瘤细胞融合伙伴贡献，以及相关的.β。链，由正常 T 细胞成分贡献。因此，令人惊讶的是，相同的α。链可以有助于识别 I 类和 II 类 MHC 分子。此外，通过体外细胞融合随机产生的两个独立示例杂合受体分子识别 MHC 的发现支持了 T 细胞库对 MHC 具有内在亲和力的理论。
The receptors of two T cell hybridomas that recognize class I and class II major histocompatibility complex (MHC) molecules, respectively, have been compared. In both cases these receptors are hybrid molecules formed as a result of cellular fusion. The receptors contain the same .alpha. chain, contributed by the tumor cell fusion partner, and related .beta. chains, contributed by the normal T cell component. Thus, surprisingly, the same .alpha. chain can contribute to recognition of class I and class II MHC molecules. Moreover, the finding that two independent examples hybrid receptor molecules created randomly by in vitro cell fusion recognize MHC supports the theory that the T cell repertoire has an intrinsic affinity for MHC.