The Time Is Right to Focus on Model Organism Metabolomes.
The Time Is Right to Focus on Model Organism Metabolomes.
复制标题
DOI：
10.3390/metabo6010008
复制
发表时间：
2016-02-15
期刊：
影响因子：
4.1
通讯作者：
Viant MR
中科院分区：
文献类型：
--
作者：
Edison AS;Hall RD;Junot C;Karp PD;Kurland IJ;Mistrik R;Reed LK;Saito K;Salek RM;Steinbeck C;Sumner LW;Viant MR
模式生物是生物和生物医学研究的重要组成部分，可用于研究特定的生物过程。这些生物体在一定程度上被选作简易的实验研究。然而，同样重要的是，对少数模式生物的深入研究产生了重要的协同效应，因为在一个科学领域对特定生物的发现有助于揭示其他领域的生物过程，甚至对其他生物也是如此。此外，为每个模式生物体汇编的广泛知识库使人们能够系统地了解这些物种，从而增强了包括人类在内的所有生物体的整体生物学和生物医学知识。在广泛的基因组学研究的基础上，我们认为现在是时候集中精力研究模型生物代谢组了。我们提出了模式生物代谢组学研究的一个重大挑战：识别所有代谢物并将其映射到代谢途径上，开发模式生物的定量代谢模型，并在进化代谢组学的背景下将生物代谢途径联系起来，即叶代谢组学。这些努力应该集中在微生物、动植物研究中的一系列已建立的模式生物上。
Model organisms are an essential component of biological and biomedical research that can be used to study specific biological processes. These organisms are in part selected for facile experimental study. However, just as importantly, intensive study of a small number of model organisms yields important synergies as discoveries in one area of science for a given organism shed light on biological processes in other areas, even for other organisms. Furthermore, the extensive knowledge bases compiled for each model organism enable systems-level understandings of these species, which enhance the overall biological and biomedical knowledge for all organisms, including humans. Building upon extensive genomics research, we argue that the time is now right to focus intensively on model organism metabolomes. We propose a grand challenge for metabolomics studies of model organisms: to identify and map all metabolites onto metabolic pathways, to develop quantitative metabolic models for model organisms, and to relate organism metabolic pathways within the context of evolutionary metabolomics, i.e., phylometabolomics. These efforts should focus on a series of established model organisms in microbial, animal and plant research.