Nonparametric linkage analysis between schizophrenia and candidate genes of dopaminergic and serotonergic systems.
Nonparametric linkage analysis between schizophrenia and candidate genes of dopaminergic and serotonergic systems.
复制标题
精神分裂症与多巴胺能和血清素能系统候选基因之间的非参数连锁分析。
DOI：
10.1017/s109285290000924x
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发表时间：
2004
期刊：
影响因子：
3.3
通讯作者：
Pato,CarlosN
中科院分区：
文献类型：
--
作者：
Ambrósio,AldaM;Kennedy,JamesL;Macciardi,Fabio;Coelho,Isabel;Soares,MariaJ;Oliveira,CatarinaR;Pato,MicheleT;Pato,CarlosN
BackgroundAlterations in dopaminergic and serotonergic systems have been implicated in the pathophysiology of schizophrenia for many years. This study was performed to assess the possible involvement of the dopamine receptor genes D2 (DRD2), D3, D4, serotonin receptor genes 1Dα, 1Dβ, and 2A in the etiology of schizophrenia.MethodsWe examined 33 multiplex schizophrenic families from Portugal.ResultsLinkage analysis performed by GENE-HUNTER showed nonsignificant linkage for these genes. A maximum nonparametric linkage score of 1.635 (P=.032) at DRD2 gene was observed, and this finding suggests DRD2 gene for further studies.Conclusionthe polymorphisms studied at dopamine receptor genes D3, D4, serotonin receptor genes 1Dα, 1Dβ, and 2A do not have a major effect in susceptibility to schizophrenia in a Portuguese population.
