Regional cerebral hypoperfusion in patients with celiac disease
Regional cerebral hypoperfusion in patients with celiac disease
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DOI：
10.1016/j.amjmed.2003.09.037
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发表时间：
2004-03-01
影响因子：
5.9
通讯作者：
Gasbarrini, G
中科院分区：
文献类型：
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作者：
Addolorato, G;Di Giuda, D;Gasbarrini, G
背景：大约10%的乳糜泻患者发生神经系统和精神疾病。虽然这些改变中的一些对无麸质饮食有反应，但这些异常的病因尚不确定。由于一个病例报告，脑灌注不足的腹腔患者解决后，无麸质饮食，我们研究了未经治疗的腹腔患者，治疗腹腔患者，和健康controls.METHODS的脑灌注变化：共15个未经治疗的腹腔患者没有影响脑灌注的条件下，没有神经或精神疾病以外的焦虑或抑郁症。我们还研究了15名乳糜泻患者，他们在近一年的无麸质饮食中，以及24名性别和年龄相似的健康志愿者。所有受试者进行了脑单光子发射计算机断层扫描examination.Results：15个未经治疗的腹腔患者，11（73%）有至少一个低灌注脑区，相比之下，只有1（7%）的15个腹腔患者无麸质饮食，没有控制（P = 0.01）。脑灌注明显降低（P
BACKGROUND: Neurological and psychiatric disorders occur in approximately 10% of patients with celiac disease. Although some of these alterations respond to a gluten-free diet, the etiology of these abnormalities is uncertain. Because of a case report that cerebral hypoperfusion in a celiac patient resolved after a gluten-free diet, we studied brain perfusion changes in untreated celiac patients, treated celiac patients, and healthy controls.METHODS: A total of 15 untreated celiac patients without conditions affecting brain perfusion were enrolled; none had neurological or psychiatric disorders other than anxiety or depression. We also studied 15 celiac patients who were on a gluten-free diet for almost I year, and 24 healthy volunteers of similar sex and age. All subjects under-went cerebral single photon emission computed tomography examination.RESULTS: Of the 15 untreated celiac patients, 11 (73%) had at least one hypoperfused brain region, compared with only 1 (7%) of the 15 celiac patients on a gluten-free diet and none of the controls (P = 0.01). Cerebral perfusion was significantly lower (P