Free radicals in anaesthesia and intensive care.
Free radicals in anaesthesia and intensive care.
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麻醉和重症监护中的自由基。
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
J. Jones
中科院分区：
文献类型：
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作者：
D. Tew;J. Jones
本综述旨在概述自由基或氧化剂在生物系统中的性质和起源，并总结它们在麻醉师感兴趣的疾病中的作用，特别是在再灌注损伤（肠、脑、心肌和移植器官）、休克/创伤、炎症/败血症和氟烷肝炎方面。在体外和动物研究检查的作用自由基和抗氧化剂在病理生理和治疗这些条件提出。一些临床研究的证据支持使用抗氧化治疗的病人也提出。
This review aims to outline the nature and origin of free radicals, or oxidants, in biological systems and to summarise their involvement in diseases of interest to anaesthetists, with particular reference to reperfusion injury (of the gut, brain, myocardium and transplanted organs), shock/trauma, inflammation/sepsis and halothane hepatitis. In-vitro and animal studies examining the role of free radicals and antioxidants in the pathophysiology and treatment of these conditions are presented. Some of the evidence from clinical studies supporting the use of antioxidant therapy in patients is also presented.