Long-term follow-up study of artificial dermis composed of outer silicone layer and inner collagen sponge
Long-term follow-up study of artificial dermis composed of outer silicone layer and inner collagen sponge
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DOI：
10.1054/bjps.2000.3426
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发表时间：
2000-12-01
期刊：
影响因子：
--
通讯作者：
Ikada, Y
中科院分区：
文献类型：
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作者：
Suzuki, S;Kawai, K;Ikada, Y
在包括日本人在内的东方人群中，供体部位肥大比白种人更明显。为了解决供体部位发病率的问题并确保移植物“成功”，我们开始了第二阶段的程序，将薄的分层皮肤移植物（STSG）移植到无细胞的“双层人造皮肤”或“人造真皮”上。自报告材料的原始版本 (OV) 以来，修订版本 (RV) 和当前版本（PV、Pelnac(R)）已分阶段开发，以消除与其使用相关的不便并降低主要制造成本。我们现在已将我们的材料（包括 OV、RV 和 PV）用于 41 名患者的 52 处皮肤缺损。 STSG 对所有患者的治疗效果几乎完美。这三种材料的长期结果在20名随访2年以上的患者中进行了调查，排除了3名供区直接关闭的患者。这些患者的最长随访期和平均随访期分别为12年5个月和6年10个月。在移植部位，20 名患者中分别有 5 名（25%）、1 名（5%）和 1 名（5%）出现因皱缩、部分脱色和肥大而引起的皱纹。在 20 名患者中，有 5 名（25%）在供体部位观察到轻微的不雅观。 20例患者综合评价中18例（90%）获得优或良结果。这些材料之间的长期随访评价没有显着差异。总之，尽管使用非常薄（约0.2毫米）的STSG，但STSG部位的长期术后外观良好；供体部位的疤痕很小，并且可以从同一供体部位重复进行皮肤移植。 (C) 2000 英国整形外科医生协会。
In the oriental population including the Japanese, donor-site hypertrophy is more pronounced than in Caucasians. To solve the problem of donor-site morbidity and to ensure graft 'take', we started the second-stage procedure of a thin split thickness skin graft (STSG) onto acellular 'bilayer artificial skin', or 'artificial dermis'. Since reporting the original version of the material (OV), a revised version (RV) and the present version (PV, Pelnac(R)) have been developed in stages to eliminate inconveniences associated with its use and to reduce the primary cost of manufacture. We have now used our materials, consisting of OV, RV and PV, on 52 skin defects in 41 patients. STSG took almost perfectly in all patients. The long-term results of these three materials were investigated in 20 patients who had been followed up for more than 2 years, excluding three patients whose donor sites had been directly closed. The longest and the mean follow-up periods of these patients were 12 years 5 months and 6 years 10 months, respectively. At the grafted sites, wrinkles caused by shrinkage, partial depigmentation and hypertrophy were observed in five (25%), one (5%) and one (5%) of the 20 patients, respectively. At the donor sites, slight unsightliness was observed in five (25%) of the 20 patients. Excellent or good results were obtained in 18 (90%) of the 20 patients in comprehensive evaluation. There were no significant differences in the long-term follow-up evaluations among these materials. In conclusion, the long-term postoperative appearance of the STSG site was good though a very thin (approximately 0.2 mm) STSG is used; scarring of the donor site was minimal and it was possible to take repeated skin grafts from the same donor site. (C) 2000 The British Association of Plastic Surgeons.