Safety and immunogenicity of a high dosage trivalent influenza vaccine among elderly subjects
Safety and immunogenicity of a high dosage trivalent influenza vaccine among elderly subjects
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DOI：
10.1016/j.vaccine.2007.08.042
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发表时间：
2007-11-01
期刊：
影响因子：
5.5
通讯作者：
Ruben, Frederick L.
中科院分区：
文献类型：
--
作者：
Couch, Robert B.;Winokur, Patricia;Ruben, Frederick L.
为了提高对流感疫苗的免疫应答，将含有60mgHA的三价灭活疫苗(A/H3N2、A/H1N1、B)与含有15mgHA的许可疫苗进行比较。高剂量的受试者报告了更多的局部和全身反应，但只有局部疼痛和肌痛显着增加。大剂量疫苗在总组以及接种和未接种前一年的受试者中，对所有三种疫苗病毒的血凝抑制(HAI)和中和试验中的血清抗体增加的频率都更高(>；=4倍)。在两种血清学试验中，高剂量组获得的抗体平均滴度、抗体增加的幅度和最终HAI抗体滴度>；=1：32、>；=1：和>；=1：128的人的频率都较高，在两种血清学试验中，对所有组和所有疫苗病毒都是如此。这些增强的免疫反应应该会增强老年人对流感的保护。(C)2007爱思唯尔有限公司。保留所有权利。
To improve immune responses to influenza vaccine, a trivalent inactivated vaccine containing 60 mu g of the HA of each component (A/H3N2, A/H1N1, B) was compared to a licensed vaccine containing 15 mu g of the HA of each. More local and systemic reactions were reported by subjects given the high dosage but only local pain and myalgias were significantly increased. The high dosage vaccine induced a higher frequency of serum antibody increases (>= 4-fold) in both hemagglutination-inhibiting (HAI) and neutralization tests for all three vaccine viruses in the total group as well as subjects vaccinated and those not vaccinated the previous year. Mean titers of antibody attained, the magnitude of antibody increases and the frequencies of persons with final HAI antibody titers >= 1:32, >= 1:64, and >= 1: 128 were all greater for the high dosage group in both serologic tests, for all groups, and for all vaccine viruses. These increased immune responses should provide increased protection against influenza in the elderly. (c) 2007 Elsevier Ltd. All rights reserved.