2-DECENOIC ACID ETHYL ESTER, A DERIVATIVE OF UNSATURATED MEDIUM-CHAIN FATTY ACIDS, FACILITATES FUNCTIONAL RECOVERY OF LOCOMOTOR ACTIVITY AFTER SPINAL CORD INJURY
2-DECENOIC ACID ETHYL ESTER, A DERIVATIVE OF UNSATURATED MEDIUM-CHAIN FATTY ACIDS, FACILITATES FUNCTIONAL RECOVERY OF LOCOMOTOR ACTIVITY AFTER SPINAL CORD INJURY
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DOI：
10.1016/j.neuroscience.2010.10.004
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发表时间：
2010-12-29
期刊：
影响因子：
3.3
通讯作者：
Furukawa, S.
中科院分区：
文献类型：
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作者：
Hirakawa, A.;Shimizu, K.;Furukawa, S.
越来越多的证据表明，ω-3多不饱和脂肪酸（PUFAs）在各种神经元损伤的动物模型中具有治疗潜力。然而，很少有研究考察中链脂肪酸（MCFAs）对神经元损伤的作用。并发现暴露于反式2-癸烯酸乙酯（DAEE）显著激活培养的皮层神经元中的细胞外信号调节蛋白激酶1和2（ERK 1/2）。因此，我们检测了DAEE治疗对脊髓损伤大鼠模型的影响脊髓半切后给药（150 μ g/kg体重）可改善功能恢复，缩小病变大小，增加ERK 1/2的激活，增强bcl 2和脑源性神经营养因子（BDNF）mRNA的表达脊髓损伤部位此外，它还增加了脊髓损伤后的神经元存活这些结果表明DAEE将成为减少脊髓原发性物理损伤后观察到的继发性损伤的有前途的工具的可能性（C）2010 IBRO由Elsevier Ltd出版版权所有
There is increasing evidence that omega 3 polyunsaturated fatty acids (PUFAs) have therapeutic potential in various animal models of neuronal injury However, very few studies have examined the effect of medium chain fatty acids (MCFAs) on neuronal injury So in the present study we synthesized various MCFAs and their derivatives, and found that exposure to trans 2-decenoic acid ethyl ester (DAEE) markedly activated extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) in cultured cortical neurons There fore, we examined the effect of DAEE treatment on a rat model of spinal cord injury DAEE (150 mu g/kg body weight) administered after hemisection of the spinal cord resulted in improved functional recovery, decreased the lesion size, in creased the activation of ERK1/2, and enhanced the expression of bcl 2 and brain-derived neurotrophic factor (BDNF) mRNA in the injury site of the spinal cord Furthermore, it also increased neuronal survival after spinal cord injury These results indicate that the possibility that DAEE will become a promising tool for reducing the secondary damage observed following primary physical injury to the spinal cord (C) 2010 IBRO Published by Elsevier Ltd All rights reserved