Urine interleukin-18 and cystatin-C as biomarkers of acute kidney injury in critically ill neonates.
Urine interleukin-18 and cystatin-C as biomarkers of acute kidney injury in critically ill neonates.
复制标题
尿液白细胞介素 18 和胱抑素 C 作为危重新生儿急性肾损伤的生物标志物
DOI：
10.1007/s00467-011-2072-x
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发表时间：
2012-05
影响因子：
3
通讯作者：
Feng, Xing
中科院分区：
文献类型：
--
作者：
Li, Yanhong;Fu, Chenlu;Zhou, Xiaofei;Xiao, Zhihui;Zhu, Xueming;Jin, Meifang;Li, Xiaozhong;Feng, Xing
关键词：
BackgroundUrinary interleukin-18 and cystatin-C are suggested to be biomarkers for predicting acute kidney injury (AKI). The aims of this study are to examine whether the urinary concentrations of interleukin-18 and cystatin-C vary with gestational age and other factors in non-AKI control neonates, and to determine whether urinary interleukin-18 and cystatin-C can predict AKI development in non-septic critically ill neonates, independently of potential confounders.MethodsWe enrolled 62 non-septic critically ill neonates. Urine was collected every 48–72 h during the first 10 days of life.ResultsUrinary concentration of cystatin-C, but not interleukin-18, decreased with increasing gestational age and body weight, but not with increasing postnatal age in non-AKI control neonates. Both urinary interleukin-18 and cystatin-C were associated with AKI, even after controlling for gestational and postnatal age, birth weight, gender, Apgar score and the score for neonatal acute physiology in non-septic critically ill neonates. Urinary interleukin-18 and cystatin-C had odds ratios of 2.27 and 2.07, and achieved the area under-the-receiver-operating-characteristic curve of 0.72 and 0.92, respectively, for predicting AKI.ConclusionsThe urinary concentration of cystatin-C, but not interleukin-18, may decrease with increasing renal maturity. Both urinary interleukin-18 and cystatin-C are independently predictive of AKI in non-septic critically ill neonates.
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影响因子：
13.6
作者：
Parikh, CR;Abraham, E;Edelstein, CL
通讯作者：
Edelstein, CL
影响因子：
15.9
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Melnikov, VY;Faubel, S;Edelstein, CL
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Edelstein, CL
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19.6
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Akcan-Arikan, A.;Zappitelli, M.;Goldstein, S. L.
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Goldstein, S. L.
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38.9
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Royakkers, Annick A. N. M.;Korevaar, Johanna C.;van Suijlen, Jeroen D. E.;Hofstra, Lieuwe S.;Kuiper, Michael A.;Spronk, Peter E.;Schultz, Marcus J.;Bouman, Catherine S. C.
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Bouman, Catherine S. C.
影响因子：
19.6
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Koyner, Jay L.;Bennett, Michael R.;Worcester, Elaine M.;Ma, Qing;Raman, Jai;Jeevanandam, Valluvan;Kasza, Kristen E.;Connor, Michael F. O';Konczal, David J.;Trevino, Sharon;Devarajan, Prasad;Murray, Patrick T.
通讯作者：
Murray, Patrick T.