Single-Molecule Sensitivity in Optical Absorption at Room Temperature
Single-Molecule Sensitivity in Optical Absorption at Room Temperature
复制标题
DOI：
10.1021/jz101426x
复制
发表时间：
2010-12-02
影响因子：
5.7
通讯作者：
Sandoghdar, Vahid
中科院分区：
文献类型：
--
作者：
Kukura, Philipp;Celebrano, Michele;Sandoghdar, Vahid
对凝聚态物质的灵敏检测在基础研究以及分子分析和诊断等前沿应用中至关重要。直到最近，所有现有的在室温下检测单分子的方法都需要高效的荧光团。在这里，我们首次证明，单分子也可以通过标准的无调制吸收测量来检测。我们的工作将单分子检测扩展到一大类吸收光但不能有效发荧光的材料。
Sensitive detection of condensed matter is of utmost importance in fundamental research as well as cutting-edge applications such as molecular analytics and diagnostics. Until very recently, all existing methods for the detection of single molecules at room temperature have required highly efficient fluorophores. Here we demonstrate, for the first time that single molecules can also be detected via standard modulation-free absorption measurements. Our work extends single-molecule detection to a huge class of materials that absorb light but do not fluoresce efficiently.