Hollow polylactic acid microcapsules fabricated by gas/oil/water and bubble template methods
Hollow polylactic acid microcapsules fabricated by gas/oil/water and bubble template methods
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气/油/水和气泡模板法制备中空聚乳酸微胶囊
DOI：
10.1039/c3ta12587d
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发表时间：
2013
影响因子：
11.9
通讯作者：
Hirofumi DaiguJi and Fumio Takemura
中科院分区：
文献类型：
--
作者：
Daichi Sakurai;Jay Jesus Molino;Hirofumi DaiguJi and Fumio Takemura
空心胶囊是充满气体的球形颗粒。直径几微米的可生物降解空心胶囊有望用作诊断超声造影剂和药物输送系统的载体，而直径几十微米的空心可生物降解胶囊已广泛应用于各种工程应用和医疗和制药应用，可减轻材料的重量并改善隔热和隔音效果。在这项研究中，基于微泡的性质，通过两种不同的方法制备了直径为 10-20 μm 和 1-2 μm 的均匀尺寸的中空聚乳酸 (PLA) 微胶囊。一种方法基于分散在连续水相中的PLA有机溶液微滴内部微泡的生长和/或聚结，另一种方法基于被PLA覆盖的独立微泡从毫滴自发释放到连续相中。这些方法均不使用微流体装置，因此在不影响均匀性的情况下具有大规模生产的巨大潜力。
Hollow capsules are gas-filled spherical particles. Hollow biodegradable capsules with a diameter of a few microns are expected to be used as diagnostic ultrasound contrast agents and carriers of drug-delivery systems, while those with a diameter of a few tens of microns have been widely used in various engineering applications and medical and pharmaceutical applications, providing weight reduction of the material and improved thermal and acoustical insulation. In this study, uniformly sized hollow polylactic acid (PLA) microcapsules with diameters of 10–20 μm and 1–2 μm have been fabricated by two different methods, both based on the nature of microbubbles. One method is based on the growth and/or coalescence of microbubbles inside microdroplets of PLA organic solution dispersed in a continuous aqueous phase, and the other one is based on the spontaneous release of independent microbubbles covered with PLA from millidroplets into the continuous phase. Neither of these methods uses microfluidic devices, and they have thus high potential for mass production without compromising the uniformity.