Association between ideal cardiovascular health and telomere length in participants older than 55 years old from the SUN cohort
Association between ideal cardiovascular health and telomere length in participants older than 55 years old from the SUN cohort
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DOI：
10.1016/j.rec.2021.04.002
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发表时间：
2022-04-01
影响因子：
5.9
通讯作者：
Marti, Amelia
中科院分区：
文献类型：
--
作者：
Alonso-Pedrero, Lucia;Ojeda-Rodriguez, Ana;Marti, Amelia
导言和目标：端粒是位于染色体末端的非编码区，其缩短与危险因素和心血管疾病有关。本研究的目的是评估理想的心血管健康（生活的简单7）和短端粒的子样本中的参与者年龄超过55岁的Seguimiento大学纳瓦拉（SUN）study.Methods的几率之间的关联：我们包括886名参与者年龄超过55岁（645名男性和241名女性）。使用实时定量聚合酶链反应测量端粒长度。美国心脏协会将心血管健康评分定义为7个关键风险因素（吸烟状况、体力活动、饮食、体重指数、血压、总胆固醇和空腹血糖）的综合评分，每个因素0 - 2分。我们将该评分分为三分之一，即差（0-9分）、中等（10-11分）和理想（12-14分）。端粒短的几率定义为端粒长度低于第20百分位数。结果：理想心血管健康状况较高的个体端粒短的患病率较低（调整OR，0.60; 95%CI，0.34-1.05; P趋势= 0.052）。这种关联在男性中具有统计学显著性（调整后的OR，0.37; 95%CI，0.17-0.83; P趋势= 0.025），但在women.Conclusions：在SUN人群中，心血管健康评分和短端粒之间存在负相关，尤其是在55岁以上的男性中。(C)2022年西班牙心脏病学会。由Elsevier Espana出版，S.L.U.
Introduction and objectives: Telomeres are noncoding regions located at the end of chromosomes and their shortening has been associated with risk factors and cardiovascular disease. The aim of this study was to evaluate the association between ideal cardiovascular health (Life's simple 7) and the odds of having short telomeres in a subsample of participants older than 55 years from the Seguimiento Universidad de Navarra (SUN) study.Methods: We included 886 participants older than 55 years (645 men and 241 women). Telomere length was measured using a real-time quantitative polymerase chain reaction. Cardiovascular health score was defined by the American Heart Association as a composite score of 7 key risk factors (smoking status, physical activity, diet, body mass index, blood pressure, total cholesterol, and fasting blood glucose) with 0 to 2 points for each factor. We categorized this score in tertiles as poor (0-9 points), intermediate (10-11 points) and ideal (12-14 points). The odds of having short telomeres was defined as telomere length below the 20th percentile.Results: Individuals with higher ideal cardiovascular health had a lower prevalence of having short telomeres (adjusted OR, 0.60; 95%CI, 0.34-1.05; P trend = .052). This association was statistically significant in men (adjusted OR, 0.37; 95%CI, 0.17-0.83; P trend = .025) but not in women.Conclusions: An inverse association between cardiovascular health score and short telomeres was found especially for men older than 55 years in the SUN population. (C) 2022 Sociedad Espanola de Cardiologia. Published by Elsevier Espana, S.L.U.