Antibodies to squalene in Gulf War Syndrome
Antibodies to squalene in Gulf War Syndrome
复制标题
DOI：
10.1006/exmp.1999.2295
复制
发表时间：
2000-02-01
影响因子：
3.6
通讯作者：
Garry, RF
中科院分区：
文献类型：
--
作者：
Asa, PB;Cao, Y;Garry, RF
海湾战争综合症（GWS）是一种多系统疾病，困扰着许多海湾战争时期的退伍军人。GWS的分子病理学基础尚未建立，我们试图确定角鲨烯抗体的存在是否与GWS的体征和症状的存在相关。这项盲法队列研究的参与者是1990-1991年期间在沙漠盾牌/沙漠风暴中服役的免疫个体。他们包括144名海湾战争时期的退伍军人或军事雇员（盲法研究中有58人），48名献血者，40名系统性红斑狼疮患者，34名硅胶乳房植入体接受者和30名慢性疲劳综合征患者。测定血清抗角鲨烯抗体。在我们的小队列中，绝大多数（95%）明显患病的GWS患者有角鲨烯抗体。所有（100%）在沙漠盾牌/沙漠风暴中接种疫苗的GWS患者没有部署，但与部署的患者有相同的体征和症状，有角鲨烯抗体。相比之下，没有（0%）部署的波斯湾退伍军人没有表现出GWS的迹象和症状有角鲨烯抗体。无论是特发性自身免疫性疾病患者还是健康对照组都没有检测到血清角鲨烯抗体。大多数有症状的GWS患者血清中有角鲨烯抗体。(C)北京大学出版社.
Gulf War Syndrome (GWS) is a multisystemic illness afflicting many Gulf War-era veterans. The molecular pathological basis for GWS has not been established We sought to determine whether the presence of antibodies to squalene correlates with the presence of signs and symptoms of GWS. Participants in this blinded cohort study were individuals immunized for service in Desert Shield/Desert Storm during 1990-1991. They included 144 Gulf War-era veterans or military employees (58 in the blinded study), 48 blood donors, 40 systemic lupus erythematosus patients, 34 silicone breast implant recipients, and 30 chronic fatigue syndrome patients. Serum antibodies to squalene were measured. In our small cohort, the substantial majority (95%) of overtly ill deployed GWS patients had antibodies to squalene. All (100%) GWS patients immunized for service in Desert Shield/Desert Storm who did not deploy, but had the same signs and symptoms as those who did deploy, had antibodies to squalene. In contrast, none (0%) of the deployed Persian Gulf veterans not showing signs and symptoms of GWS have antibodies to squalene. Neither patients with idiopathic autoimmune disease nor healthy controls had detectable serum antibodies to squalene. The majority of symptomatic GWS patients had serum antibodies to squalene. (C) 2000 Academic Press.