Factors Influencing Discussion of Cancer Genetic Testing with Health-Care Providers in a Population-Based Survey.
Factors Influencing Discussion of Cancer Genetic Testing with Health-Care Providers in a Population-Based Survey.
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DOI：
10.1159/000515465
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发表时间：
2021
影响因子：
1.7
通讯作者：
Shete S
中科院分区：
文献类型：
--
作者：
Makhnoon S;Yu R;Cunningham SA;Peterson SK;Shete S
与医疗保健提供者（HCP）讨论癌症基因检测是必要的，以进行检测，为癌症风险评估和预防提供信息。鉴于肿瘤学基因检测实践的快速发展，我们描述了当前人群水平癌症基因检测行为的现状。对德克萨斯州人群的非概率样本（N= 2，029）进行了问卷调查，其中包括与HCP进行癌症基因检测讨论相关的项目。总体而言，11%的受访者与HCP讨论了癌症基因检测。在多因素分析中，讨论与乳腺癌/卵巢癌/结肠癌个人史（OR=11.57，95%CI =5.34-25.03）、其他癌症个人史（OR=3.18，95%CI =1.69-5.97）和健康信息寻求行为（OR=1.73，95%CI =1.12-2.66）显著相关。令人惊讶的是，与不相信遗传性癌症易感性导致癌症的人相比，认为遗传性易感性加上其他可改变的风险因素导致癌症的受访者不太可能讨论基因检测（OR=0.54，95%CI =0.36-0.79）。高讨论率可能归因于公众对基因检测的认识提高，以及采用更具包容性的临床基因检测指南。研究结果表明，需要努力提高公众对基因检测在个性化癌症风险评估和癌症预防中的效用的认识。
Discussion of cancer genetic testing with healthcare providers (HCPs) is necessary to undergo testing to inform cancer risk assessment and prevention. Given the rapid evolution in genetic testing practice in oncology, we describe the current landscape of population-level cancer genetic testing behaviors. A questionnaire including items regarding discussion of cancer genetic testing with HCPs was administered to a non-probability sample (N=2,029) of the Texas population. Overall, 11% of respondents discussed cancer genetic testing with HCPs. In multivariable analysis, discussion was significantly related to having a personal history of breast/ovarian/colon cancer (OR=11.57, 95% CI=5.34–25.03), personal history of other cancer (OR=3.18, 95% CI=1.69–5.97), and health information seeking behaviors (OR=1.73, 95% CI=1.12–2.66). Surprisingly, respondents who believed that inherited predispositions in addition to other modifiable risk factors cause cancer were less likely to discuss genetic testing compared to those who did not believe that inherited cancer predispositions cause cancer (OR=0.54, 95% CI=0.36–0.79). The high discussion rate may be attributed to increased public awareness of genetic testing, and adoption of more inclusive clinical genetic testing guidelines. The findings suggest that efforts to increase public awareness of the utility of genetic testing on personalized cancer risk assessment and cancer prevention is needed.
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影响因子：
3.6
作者：
Kasting, Monica L.;Conley, Claire C.;Vadaparampil, Susan T.
通讯作者：
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影响因子：
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通讯作者：
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作者：
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通讯作者：
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