Early Dissemination of NDM-1-and OXA-181-Producing Enterobacteriaceae in Indian Hospitals: Report from the SENTRY Antimicrobial Surveillance Program, 2006-2007
Early Dissemination of NDM-1-and OXA-181-Producing Enterobacteriaceae in Indian Hospitals: Report from the SENTRY Antimicrobial Surveillance Program, 2006-2007
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DOI：
10.1128/aac.01497-10
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发表时间：
2011-03-01
影响因子：
4.9
通讯作者：
Mendes, Rodrigo E.
中科院分区：
文献类型：
--
作者：
Castanheira, Mariana;Deshpande, Lalitagauri M.;Mendes, Rodrigo E.
在2006年和2007年在印度分离的39株碳青霉烯类耐药肠杆菌科（总体占2.7%;大肠埃希菌、阴沟肠杆菌和肺炎克雷伯菌菌株）中，15株菌株携带bla（NDM-1），10株携带编码碳青霉烯酶OXA-48变体的基因，命名为bla（OXA-181）。一种大肠埃希clobacillus菌株含有bla（VIM-6），而K.携带bla（OXA-181）的pneumoniae菌株也具有bla（VIM-5）。多脉冲场凝胶电泳模式和克隆传播内和网站之间进行了观察。早在2006年，产生NDM-1的分离株就在印度卫生保健机构传播。
Among 39 carbapenem-resistant Enterobacteriaceae (2.7% overall; Escherichia coli, Enterobacter cloacae, and Klebsiella pneumoniae strains) isolated in 2006 and 2007 in India, 15 strains carried bla(NDM-1) and 10 harbored a gene encoding a variant of the carbapenemase OXA-48, named bla(OXA-181). One E. cloacae strain harbored bla(VIM-6), and one K. pneumoniae strain carrying bla(OXA-181) also possessed bla(VIM-5). Multiple pulsed-field gel electrophoresis patterns and clonal dissemination within and among sites were observed. Isolates producing NDM-1 were disseminated in Indian health care facilities as early as 2006.