Prostate-specific antigen (PSA) bounce and other fluctuations: Which biochemical relapse definition is least prone to PSA false calls? An analysis of 2030 men treated for prostate cancer with external beam or brachytherapy with or without adjuvant androgen deprivation therapy
Prostate-specific antigen (PSA) bounce and other fluctuations: Which biochemical relapse definition is least prone to PSA false calls? An analysis of 2030 men treated for prostate cancer with external beam or brachytherapy with or without adjuvant androgen deprivation therapy
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DOI：
10.1016/j.ijrobp.2005.10.008
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发表时间：
2006-04-01
影响因子：
7
通讯作者：
Pickles, T
中科院分区：
文献类型：
--
作者：
Pickles, T
目的：为了确定前列腺特异性抗原（PSA）复发的假呼叫（FC）率，根据9种不同的PSA复发定义后，PSA波动（反弹）发生后，外照射放射治疗（EBRT）或近距离放射治疗，有或无辅助雄激素剥夺therapy.Methods和材料：前瞻性数据库的2030例进行了分析。根据美国放射治疗和肿瘤学会（ASTRO）、温哥华、阈值+ n和最低值+ n定义对完整数据集的前列腺特异性抗原复发进行评分，然后与截断数据集进行比较，删除反弹高度之后的数据。FC率计算每个definition.Results：弹跳率，这个非常自由的弹跳定义，是58%与EBRT和84%与近距离放射治疗。最低值+ 2和+ 3定义的FC率最低（分别为2.2%和1.6%），低阈值和ASTRO定义的FC率最高（分别为32%和18%）。ASTRO的定义是特别容易FC雄激素剥夺治疗时，与辐射（24%）。讨论：新的定义的生化非证据的疾病，更强大的ASTRO的定义已被确定。FC率最低的是最低点+ 2和最低点+ 3定义，2005年放射治疗肿瘤组-ASTRO共识小组会议正在考虑用这两种定义取代ASTRO定义。(c)2006年爱思唯尔公司
Purpose: To determine the false call (FC) rate for prostate-specific antigen (PSA) relapse according to nine different PSA relapse definitions after a PSA fluctuation (bounce) has occurred after external beam radiation therapy (EBRT) or brachytherapy, with or without adjuvant androgen deprivation therapy.Methods and Materials: An analysis of a prospective database of 2030 patients was conducted. Prostate-specific antigen relapse was scored according to the American Society for Therapeutic Radiology and Oncology (ASTRO), Vancouver, threshold + n, and nadir + n definitions for the complete data set and then compared against a truncated data set, with data subsequent to the height of the bounce deleted. The FC rate was calculated for each definition.Results: The bounce rate, with this very liberal definition of bounce, was 58% with EBRT and 84% with brachytherapy. The FC rate was lowest with nadir + 2 and + 3 definitions (2.2% and 1.6%, respectively) and greatest with low-threshold and ASTRO definitions (32% and 18%, respectively). The ASTRO definition was particularly susceptible to FC when androgen deprivation therapy was used with radiation (24%).Discussion: New definitions of biochemical non-evidence of disease that are more robust than the ASTRO definition have been identified. Those with the least FC rates are the nadir + 2 and nadir + 3 definitions, both of which are being considered to replace the ASTRO definition by the 2005 meeting of the Radiation Therapy Oncology Group-ASTRO consensus panel. (c) 2006 Elsevier Inc.