Epidemiology and burden of systemic lupus erythematosus in a Southern European population: data from the community-based lupus registry of Crete, Greece
Epidemiology and burden of systemic lupus erythematosus in a Southern European population: data from the community-based lupus registry of Crete, Greece
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DOI：
10.1136/annrheumdis-2017-211206
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发表时间：
2017-12-01
影响因子：
27.4
通讯作者：
Bertsias, George K.
中科院分区：
文献类型：
--
作者：
Gergianaki, Irini;Fanouriakis, Antonis;Bertsias, George K.
目的系统性红斑狼疮（SLE）的人群研究已有报道，但缺乏基于社区的、个案验证的、综合性的研究报告。我们研究了1999- 2013年克里特岛SLE的流行病学和负担。方法多学科病例发现包括≥ 15岁的患者。根据ACR 1997、SLICC 2012标准和风湿病专家诊断确定病例，并通过综合病历、管理和患者生成的数据进行验证。（95% CI 6.8 - 7.9）/100 000人/年，女性趋势稳定，但男性增加，平均（+/- SD）诊断年龄为43（+/- 15）岁。校正和粗患病率（2013年12月）分别为123.4（113.9至132.9）和143（133至154）/10（5）（城市165/10（5）vs农村123/10（5），p
Objectives Several population-based studies on systemic lupus erythematosus (SLE) have been reported, yet community-based, individual-case validated, comprehensive reports are missing. We studied the SLE epidemiology and burden on the island of Crete during 1999-2013.Methods Multisource case-finding included patients >= 15 years old. Cases were ascertained by the ACR 1997, SLICC 2012 criteria and rheumatologist diagnosis, and validated through synthesis of medical charts, administrative and patient-generated data.Results Overall age-adjusted/sex-adjusted incidence was 7.4 (95% CI 6.8 to 7.9) per 100 000 persons/year, with stabilising trends in women but increasing in men, and average (+/- SD) age of diagnosis at 43 (+/- 15) years. Adjusted and crude prevalence (December 2013) was 123.4 (113.9 to 132.9) and 143 (133 to 154)/10(5) (165/10(5) in urban vs 123/10(5) in rural regions, p