Comparison between the effects of ethanol and diazepam on spatial working memory in the rat.
Comparison between the effects of ethanol and diazepam on spatial working memory in the rat.
复制标题
乙醇和地西泮对大鼠空间工作记忆影响的比较。
DOI：
10.1007/s002130050399
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发表时间：
1997
影响因子：
3.4
通讯作者：
Best,PJ
中科院分区：
文献类型：
--
作者：
White,AM;Simson,PE;Best,PJ
本研究比较了乙醇和地西泮对一项任务的影响，该任务允许在每天内评估空间工作记忆和空间信息的获取。在每天的第一次试验中，受试者在六臂径向臂迷宫中展示食物奖励的空间位置。在随后的9次自由选择试验中，受试者被强化为返回相同的空间位置。食物奖励的位置在不同的日子里有所不同。因此，在任何一次试验中，正确的选择要求受试者记住在当天的前一次试验中食物是在哪里吃的。通过分析每天9次自由选择试验中犯下的错误总数来评估乙醇和地西泮对工作记忆的影响。通过比较每天前三次试验期间犯下的错误数量与每天最后三次试验期间犯下的错误数量，评估乙醇和地西泮对日内采集的影响。乙醇和地西泮都产生了剂量依赖性的工作记忆错误增加，并且都没有损害日内收购。本研究的结果提供了进一步的证据乙醇和苯二氮卓类受体激动剂对学习和记忆的影响之间的相似性，并与乙醇的GABA在GABAA受体的增强作用有助于乙醇产生的学习和记忆障碍的假设是一致的。
The present study compared the effects of ethanol and diazepam on a task that allows for the assessment of both spatial working memory and the acquisition of spatial information within each day. During the first trial of each day, subjects were shown the spatial location of a food reward on a six-arm radial-arm maze. During nine subsequent free-choice trials, subjects were reinforced for returning to that same spatial location. The location of the food reward varied across days. Thus, choosing correctly on any given trial required subjects to remember where food had been received during the previous trials of that day. The effects of ethanol and diazepam on working memory were assessed by analyzing the overall number of errors committed during the nine free-choice trials of each day. The effects of ethanol and diazepam on within-day acquisition were assessed by comparing the number of errors committed during the first three trials of each day to the number of errors committed during the last three trials of each day. Ethanol and diazepam both produced dose-dependent increases in working memory errors, and both did so without impairing within-day acquisition. The results of the present study provide further evidence of the similarities between the effects of ethanol and benzodiazepine receptor agonists on learning and memory, and are consistent with the hypothesis that ethanol’s potentiation of GABA at GABAAreceptors contributes to the learning and memory impairments produced by ethanol.