The basal forebrain cholinergic system and object memory in the rat.
The basal forebrain cholinergic system and object memory in the rat.
复制标题
大鼠的基底前脑胆碱能系统和物体记忆。
DOI：
10.1016/0006-8993(95)01477-2
复制
发表时间：
1996
期刊：
影响因子：
2.9
通讯作者：
Rothblat,LA
中科院分区：
文献类型：
--
作者：
Vnek,N;Kromer,LF;Wiley,RG;Rothblat,LA
大鼠与近完全破坏基底前脑胆碱能神经元的脑室内注射192 IgG-皂草素训练对象的歧视问题，然后再培训两周后，以测量保留。尽管海马和新皮层中乙酰胆碱酯酶阳性纤维显著减少，但这些动物在储蓄分数分析上与对照组没有差异。因此，基底前脑胆碱能系统可能提供支持非空间记忆的功能，但本质上不是特别的记忆。
Rats with near complete destruction of basal forebrain cholinergic neurons from intracerebroventricular injections of 192 IgG-saporin were trained on object discrimination problems and then retrained two weeks later to measure retention. Despite dramatic reductions of acetylcholinesterase-positive fibers in hippocampus and neocortex, these animals did not differ from controls on an analysis of savings scores. Thus, the basal forebrain cholinergic system may serve functions that support non-spatial memory but are not specifically mnemonic in nature.