Effects of an oral appliance with different mandibular protrusion positions at a constant vertical dimension on obstructive sleep apnea
Effects of an oral appliance with different mandibular protrusion positions at a constant vertical dimension on obstructive sleep apnea
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DOI：
10.1007/s00784-009-0298-9
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发表时间：
2010-06-01
影响因子：
3.4
通讯作者：
Naeije, Machiel
中科院分区：
文献类型：
--
作者：
Aarab, Ghizlane;Lobbezoo, Frank;Naeije, Machiel
该研究的目的是评估垂直尺寸恒定的四个下颌前突位置对阻塞性睡眠呼吸暂停 (OSA) 的影响。 17 名 OSA 患者（49.2 +/- 8.5 岁）接受了可调节下颌前移装置 (MAD)。患者接受了四次多导睡眠图记录，其 MAD 按随机顺序位于最大突出的 0%、25%、50% 和 75% 处。患者的平均呼吸暂停低通气指数 (AHI) 值在前伸位置之间存在显着差异 (P < 0.000)。 25%突出位置导致AHI相对于0%位置显着降低，而在50%和75%位置，发现甚至更低的AHI值。从 50% 突出位置开始，副作用的数量较大。因此，我们建议通过在 50% 突出位置开始 MAD 治疗，在疗效和副作用之间取得加权折衷。
The aim of the study was to assess the influence of four mandibular protrusion positions, at a constant vertical dimension, on obstructive sleep apnea (OSA). Seventeen OSA patients (49.2 +/- 8.5 years) received an adjustable mandibular advancement device (MAD). The patients underwent four polysomnographic recordings with their MAD in situ at, in random order, 0%, 25%, 50%, and 75% of the maximum protrusion. The mean apnea-hypopnea index (AHI) values of the patients differed significantly between the protrusion positions (P < 0.000). The 25% protrusion position resulted in a significant reduction of the AHI with respect to the 0% position, while in the 50% and 75% positions, even lower AHI values were found. The number of side effects was larger starting at the 50% protrusion position. We therefore recommend coming to a weighted compromise between efficacy and side effects by starting a MAD treatment in the 50% protrusion position.