Synthetic and Predictive Approach to Unsymmetrical Biphenols by Iron-Catalyzed Chelated Radical-Anion Oxidative Coupling
Synthetic and Predictive Approach to Unsymmetrical Biphenols by Iron-Catalyzed Chelated Radical-Anion Oxidative Coupling
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DOI：
10.1021/jacs.5b06494
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发表时间：
2015-09-09
影响因子：
15
通讯作者：
Pappo, Doron
中科院分区：
文献类型：
--
作者：
Libman, Anna;Shalit, Hadas;Pappo, Doron
研究了铁催化的1，1，1，3，3，3-六氟丙醇氧化不对称偶联反应。基于机理的研究，电化学方法，和密度泛函理论计算，我们提出了一个通用的模型，使预测的可行性交叉偶联为一个给定的对苯酚。
An iron-catalyzed oxidative unsymmetrical biphenol coupling in 1,1,1,3,3,3-hexafluoropropan-2-ol that proceeds via a chelated radical anion coupling mechanism was developed. Based on mechanistic studies, electrochemical methods, and density functional theory calculations, we suggest a general model that enables prediction of the feasibility of cross-coupling for a given pair of phenols.