The missing link: analogous human and primate cortical gamma oscillations
The missing link: analogous human and primate cortical gamma oscillations
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DOI：
10.1016/j.neuroimage.2005.01.009
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发表时间：
2005-05-15
期刊：
影响因子：
5.7
通讯作者：
Barnes, GR
中科院分区：
文献类型：
--
作者：
Hall, SD;Holliday, IE;Barnes, GR
最近的动物研究强调功能成像信号和潜在的神经元活动之间的关系，揭示了非侵入性方法的潜在能力。然而，动物和人类研究之间有价值的信息交流仍然受到物种之间直接生理联系的有限证据的限制。在这项研究中，我们使用脑磁图（MEG）调查的发生30-70赫兹（伽马）振荡的人类视觉皮层，引起的视觉刺激的不同对比度的介绍。这些振荡，以及在动物文献中描述的，观察到在视网膜一致的位置的视觉皮层，并显示出惊人的相似性，发现在灵长类动物的视觉皮层中使用手术植入电极。的γ振荡的幅度线性增加与刺激的对比度在强相关性的γ振荡中发现的本地场电位（LFP）的猕猴。我们证明，非侵入性磁场测量的伽马振荡在人类视觉皮层一致的灵长类动物视觉皮层的激活与侵入性措施，这表明既直接代表潜在的神经元活动和人类和灵长类动物的皮层活动之间的并发症。(c)2005年爱思唯尔公司All rights reserved.
Recent animal studies highlighting the relationship between functional imaging signals and the underlying neuronal activity have revealed the potential capabilities of non-invasive methods. However, the valuable exchange of information between animal and human studies remains restricted by the limited evidence of direct physiological links between species. In this study we used magnetoencephalography (MEG) to investigate the occurrence of 30-70 Hz (gamma) oscillations in human visual cortex, induced by the presentation of visual stimuli of varying contrast. These oscillations, well described in the animal literature, were observed in retinotopically concordant locations of visual cortex and show striking similarity to those found in primate visual cortex using surgically implanted electrodes. The amplitude of the gamma oscillations increases linearly with stimulus contrast in strong correlation with the gamma oscillations found in the local field potential (LFP) of the macaque. We demonstrate that non-invasive magnetic field measurements of gamma oscillations in human visual cortex concur with invasive measures of activation in primate visual cortex, suggesting both a direct representation of underlying neuronal activity and a concurrence between human and primate cortical activity. (c) 2005 Elsevier Inc. All rights reserved.