Maternal cortisol and offspring birthweight: Results from a large prospective cohort study
Maternal cortisol and offspring birthweight: Results from a large prospective cohort study
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DOI：
10.1016/j.psyneuen.2009.10.003
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发表时间：
2010-06-01
影响因子：
3.7
通讯作者：
Bonsel, Gouke J.
中科院分区：
文献类型：
--
作者：
Goedhart, Geertje;Vrijkotte, Tanja G. M.;Bonsel, Gouke J.
母体心理社会问题可能通过母体皮质醇影响胎儿发育。这项大型前瞻性队列研究调查了2810名妇女(1)母亲皮质醇水平与后代出生体重和小于胎龄(SGA)风险的关系，以及(2)母亲皮质醇在母亲心理社会问题和胎儿生长之间的中介作用。阿姆斯特丹的孕妇在她们的第一次产前访问(+/-13周妊娠)时被问及。测定母体总皮质醇水平，并通过问卷调查收集母体心理社会指标。母亲皮质醇水平与子女出生体重呈负相关(B=-0.35；P<；.001)，与SGA呈正相关(OR=1.00；P=.027)；调整后(出生时胎龄、婴儿性别、种族、母亲年龄、产次、体重指数和吸烟)，这些影响在统计学上不显著。事后分析显示，通过一天中的时间进行缓和效果：仅在那些提供血样的女性中
Maternal psychosocial problems may affect fetal growth through maternal cortisol. This large prospective cohort study examined among 2810 women (1) the association of maternal cortisol levels with offspring birthweight and small for gestational age (SGA) risk and (2) the mediating role of maternal cortisol on the relation between maternal psychosocial problems and fetal growth. Pregnant women in Amsterdam were approached during their first prepartum visit (+/- 13 weeks gestation). Total maternal cortisol level was determined in serum and maternal psychosocial indicators were collected through a questionnaire. Maternal cortisol levels were negatively related to offspring birthweight (B = -0.35; p < .001) and positively to SGA (OR = 1.00; p =.027); after adjustment (for gestational age at birth, infant gender, ethnicity, maternal age, parity, BMI, and smoking), these effects were statistically insignificant. Post hoc analysis revealed a moderation effect by time of day: only in those women who provided a blood sample