Importance of Multidrug Efflux Pumps in the Antimicrobial Resistance Property of Clinical Multidrug-Resistant Isolates of Neisseria gonorrhoeae
Importance of Multidrug Efflux Pumps in the Antimicrobial Resistance Property of Clinical Multidrug-Resistant Isolates of Neisseria gonorrhoeae
复制标题
DOI：
10.1128/aac.00038-14
复制
发表时间：
2014-06-01
影响因子：
4.9
通讯作者：
Unemo, Magnus
中科院分区：
文献类型：
--
作者：
Golparian, Daniel;Shafer, William M.;Unemo, Magnus
药物外排泵在淋病奈瑟氏菌临床分离株中的作用迄今尚未得到研究，这些临床分离株表达广泛耐药或多药耐药表型。因此，我们评估了在此类临床分离株中，与已知输出抗菌剂（MtrC-MtrD-MtrE、MacA-MacB和NorM）能力相关的三种淋球菌外排泵丧失对抗菌剂耐药性的影响。我们报告说，几种抗菌药物的MIC，包括七种以前和现在推荐的治疗方法受到了显着影响。
The contribution of drug efflux pumps in clinical isolates of Neisseria gonorrhoeae that express extensively drug-resistant or multidrug-resistant phenotypes has heretofore not been examined. Accordingly, we assessed the effect on antimicrobial resistance of loss of the three gonococcal efflux pumps associated with a known capacity to export antimicrobials (MtrC-MtrD-MtrE, MacA-MacB, and NorM) in such clinical isolates. We report that the MIC of several antimicrobials, including seven previously and currently recommended for treatment was significantly impacted.