Autistic children and their first-degree relatives: relationships between serotonin and norepinephrine levels and intelligence.
Autistic children and their first-degree relatives: relationships between serotonin and norepinephrine levels and intelligence.
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自闭症儿童及其一级亲属：血清素和去甲肾上腺素水平与智力之间的关系。
DOI：
10.1176/jnp.2.3.268
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Freedman,DX
中科院分区：
文献类型：
--
作者：
CookJr,EH;Leventhal,BL;Heller,W;Metz,J;Wainwright,M;Freedman,DX
本文对16名孤独症儿童、21名孤独症儿童的兄弟姐妹和53名孤独症儿童的父母的全血5-羟色胺（5-HT）和血浆去甲肾上腺素（NE）进行了研究。血浆NE和全血5-HT与词汇成绩呈负相关。全血5-HT和血浆NE在有或没有自伤行为或疼痛敏感性降低史的自闭症儿童之间没有差异。18例受试者为高血压性（全血5-HT大于270 ng/ml）。对于这些受试者，血浆NE显著高于无高胆固醇血症的受试者。在10个有1名高脂血症成员的家庭中，7个有2名或2名以上高脂血症成员。对全血5-HT的熟悉程度的观察表明，将全血5-HT作为可能的遗传标记进行更大规模和更集中的研究可能是富有成效的。
Whole-blood serotonin (5-HT) and plasma norepinephrine (NE) were studied in 16 autistic children, 21 siblings of autistic children, and 53 parents of autistic children. Both plasma NE and whole-blood 5-HT were negatively correlated with vocabulary performance. Whole-blood 5-HT and plasma NE did not differ between autistic children with or without histories of self-injurious behavior or decreased pain sensitivity. Eighteen subjects were hyperserotonemic (whole-blood 5-HT greater than 270 ng/ml). For these subjects, plasma NE was significantly higher than for subjects without hyperserotonemia. Seven of 10 families with one hyperserotonemic member had two or more hyperserotonemic members. Observations of familiarity of whole-blood 5-HT suggest that larger-scale and more focused study of whole-blood 5-HT as a possible genetic marker may be productive.