Delayed rod dark adaptation in patients with Stargardt's disease.
Delayed rod dark adaptation in patients with Stargardt's disease.
复制标题
斯塔加特病患者视杆暗适应延迟。
DOI：
10.1016/s0161-6420(91)32196-1
复制
发表时间：
1991
期刊：
影响因子：
13.7
通讯作者：
Alexander,KR
中科院分区：
文献类型：
--
作者：
Fishman,GA;Farbman,JS;Alexander,KR
12例Stargardt营养不良患者均发现视杆细胞暗适应延长。所有有一个正常的恢复率在杆暗适应的早期部分，但杆恢复的后期部分的选择性延长。无论是否观察到深色脉络膜，无论是否存在萎缩性黄斑病变，这种观察结果在局限性眼底软化和广泛性眼底软化的患者中都很明显。视网膜色素上皮细胞内参与视色素再生周期的酶或细胞内转运机制的缺陷可以解释这些发现。
Twelve patients with Stargardt's dystrophy were each found to have a prolongation in rod dark adaptation. All had a normal rate of recovery during the early portion of rod dark adaptation but a selective prolongation of the later segment of rod recovery. This observation was apparent in patients with limited fundus flecks and those with extensive fundus flecks, whether or not a dark choroid was observed and independent of the presence or absence of an atrophic-appearing macular lesion. A defect within retinal pigment epithelial cells of an enzyme or intracellular transport mechanism involved in the visual pigment regeneration cycle could account for these findings.