CHEMICAL STUDIES ON TOBACCO-SMOKE .33. N'-NITROSONORNICOTINE IN TOBACCO - ANALYSIS OF POSSIBLE CONTRIBUTING FACTORS AND BIOLOGIC IMPLICATIONS
CHEMICAL STUDIES ON TOBACCO-SMOKE .33. N'-NITROSONORNICOTINE IN TOBACCO - ANALYSIS OF POSSIBLE CONTRIBUTING FACTORS AND BIOLOGIC IMPLICATIONS
复制标题
DOI：
10.1093/jnci/54.5.1237
复制
发表时间：
1975-01-01
影响因子：
10.3
通讯作者：
HOFFMANN, D
中科院分区：
文献类型：
--
作者：
HECHT, SS;ORNAF, RM;HOFFMANN, D
建立了烟草中N '-亚硝基去甲烟碱（NNN）和N' -亚硝基假木贼碱（NAB）的化学分析方法.在商业产品的未燃烧烟草中发现NNN，浓度在0.3至88.6微克/克之间。在高度发酵的鼻烟（29.1微克/克）和细切咀嚼烟草（88.6微克/克）中观察到最高水平。在所有烟草中均未检测到NAB（<0.5 ng/g）。发现了两种新的烟草成分，N' -甲氧羰去甲烟碱和N' -甲氧羰假木贼碱，并讨论了NNN的可能来源，特别是与亚硝酸盐、硝酸盐和生物碱浓度的关系，以及与pH值和烘烤的关系。生物学意义，包括可能的功能NNN（第一个从未燃烧的烟草中分离出的有机致癌物）作为一个致病因素的口腔癌的烟草咀嚼者和槟榔咀嚼者，也进行了讨论。
A chemical analytic method to determineN'nitrosonornicotine (NNN) andN' -nitrosoanabasine (NAB) in tobacco was developed. NNN was found in the unburned tobacco of commercial products at concentrations between 0.3 and 88.6 µg/g. The highest levels were observed in highly fermented snuff (29.1 p.g/g) and fine-cut chewing tobacco (88.6 µg/g). NAB was not detected (<0.5 ng/g) in any tobacco examined. Two new tobacco components,N' -carbomethoxynornicotine andN' -carbomethoxyanabasine, were found. Possible origins of NNN in tobacco were discussed, especially in relation to concentrations of nitrite, nitrate, and alkaloids, and in relation to pH and curing. Biologic implications, including the possible function of NNN (the first organic carcinogen isolated from unburned tobacco) as a causative factor in cancer of the oral cavity in tobacco chewers and betel quid chewers, were also discussed.