MORPHOLOGY AFTER TRANS-LUMINAL ANGIOPLASTY IN HUMAN-BEINGS
MORPHOLOGY AFTER TRANS-LUMINAL ANGIOPLASTY IN HUMAN-BEINGS
复制标题
DOI：
10.1056/nejm198108133050706
复制
发表时间：
1981-01-01
影响因子：
158.5
通讯作者：
FALLON, JT
中科院分区：
文献类型：
--
作者：
BLOCK, PC;MYLER, RK;FALLON, JT
经皮腔内血管成形术常用于特定患者，以减少动脉粥样硬化性外周动脉、1，2肾动脉、3456和冠状动脉的狭窄。789关于成功的腔内血管成形术的机制存在很大争议。最初假设血管腔的扩大是由于动脉粥样硬化斑块的压缩。2然而，动物实验和人体尸检研究1011121314151617表明，腔内血管成形术会导致内皮剥脱和动脉粥样硬化斑块的分裂。试图将这些发现外推到临床上成功的血管成形术的机制上，却遭到了批评，认为动脉粥样硬化的死后组织和动物模型......
PERCUTANEOUS transluminal angioplasty is frequently used in selected patients to decrease stenoses in atherosclerotic peripheral arteries,1,2renal arteries,3456and coronary arteries.789There has been much controversy over the mechanism of successful transluminal angioplasty. It was initially postulated that enlargement of the vascular lumen was due to compression of atheromatous plaque.2However, experiments in animals and autopsy studies in human beings1011121314151617have shown that transluminal angioplasty produces endothelial desquamation and splitting of the atheromatous plaque. Attempts to extrapolate these findings to the mechanism of clinically successful angioplasty have been subjected to the criticism that post-mortem tissue and animal models of atherosclerosis . . .