Mesoporous carbon nanoshells for high hydrophobic drug loading, multimodal optical imaging, controlled drug release, and synergistic therapy.
Mesoporous carbon nanoshells for high hydrophobic drug loading, multimodal optical imaging, controlled drug release, and synergistic therapy.
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DOI：
10.1039/c6nr07894j
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发表时间：
2017-01-26
期刊：
影响因子：
6.7
通讯作者：
Zhang M
中科院分区：
文献类型：
--
作者：
Wang H;Wang K;Mu Q;Stephen ZR;Yu Y;Zhou S;Zhang M
几十年来，向肿瘤细胞装载和控制释放足够的疏水药物一直是化疗的瓶颈。本文报道了一种荧光介孔碳纳米壳(FMP-CNS)的研制，它对疏水药物紫杉醇(PTX)的负载量高达~80wt%，并在1.5W/cm2的近红外辐射(825 Nm)下以可控的方式释放药物。较高的载药量主要归因于其介孔结构和FMP-CNS与PTX分子之间的超分子π堆积。FMP-CNS还具有波长可调和上转换荧光特性，因此可以作为共焦、双光子和近红外(NIR)荧光成像的光学标记。此外，我们的体外实验结果表明，FMP-CNS通过化学-光热联合治疗的协同作用显示出高的治疗效果。体内研究表明，单次瘤内注射PTX-FMP-CNS可显著抑制荷大鼠C6胶质母细胞瘤小鼠的肿瘤生长。
Loading and controlled release of sufficient hydrophobic drugs to tumor cells has been the bottleneck in chemotherapy for decades. Here we report the development of a fluorescent and mesoporous carbon nanoshell (FMP-CNS) that exhibits a loading capacity for hydrophobic drug paclitaxel (PTX) as high as ~80 wt% and releases drug in a controllable fashion under NIR irradiation (825 nm) at a intensity of 1.5 W/cm2. The high drug loading is primarily attributed to its mesoporous structure and to the supramolecular π-stacking between FMP-CNSs and PTX molecules. The FMP-CNS also exhibits wavelength-tunable and upconverted fluorescent property and thus can serve as an optical marker for confocal, two-photon, and near infrared (NIR) fluorescence imaging. Further, our in vitro results indicate that FMP-CNSs demonstrate high therapeutic efficacy through the synergistic effect of combined chemo-photothermal treatment. In vivo studies demonstrate marked suppression of tumor growth in mice bearing rat C6 glioblastoma after the administration with single intratumoral injection of PTX-loaded FMP-CNS.