Influence of catch-up growth on islet function and possible mechanisms in rats.
Influence of catch-up growth on islet function and possible mechanisms in rats.
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DOI：
10.1016/j.nut.2010.09.007
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发表时间：
2011-04
期刊：
影响因子：
4.4
通讯作者：
Lulu Chen;Wei-hong Yang;Juan Zheng;Jiaoyue Zhang;L. Yue
中科院分区：
文献类型：
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作者：
Lulu Chen;Wei-hong Yang;Juan Zheng;Jiaoyue Zhang;L. Yue
目的：本研究的目的是探讨追赶性生长如何调节胰岛功能，以及其具体机制，特别是在追赶性生长的不同阶段和不同形式。方法我们通过口服葡萄糖耐量试验来检查追赶性生长期间胰岛功能的调节，并通过测量一般生理参数、胰腺形态测量、胰岛素含量和慢性氧化应激状态来深入了解所涉及的可能机制。采用相关分析评估胰岛素/葡萄糖增量面积比与其他参数的相关性。结果追赶生长组导致胰岛功能受损，表现为胰岛素/葡萄糖增量面积比增加(P≤0.05)、β细胞相对面积较小(P≤0.05)、α细胞相对面积较大(P≤0.05)、胰岛素含量较低(P≤0.05)、一氧化氮和丙二醛浓度增加，超氧化物歧化酶浓度降低（分别 P ≤ 0.05）。随着时间的推移，这些变化变得越来越不明显。结论不同阶段和形式的追赶性生长会诱发不同程度的胰岛功能障碍，可能是通过一般生理参数、胰腺形态测量、胰岛素含量和慢性氧化应激状态的相应变化来实现的。
OBJECTIVEThe purpose of this study was to examine how catch-up growth modulated islet function and what the detailed mechanisms were, especially at various stages and in different forms, of catch-up growth.METHODSWe examined the modulation of islet function during catch-up growth by employing an oral glucose tolerance test and gained some insight into the possible mechanisms involved by measuring general physiologic parameters, pancreatic morphometry, insulin content, and the state of chronic oxidative stress. Correlation analyses were used to assess the correlation of insulin/glucose incremental area ratio to other parameters.RESULTSThe catch-up growth groups resulted in damage to islet function as shown by an increased insulin/glucose incremental area ratio (P ≤ 0.05), smaller relative area of β-cells (P ≤ 0.05), larger relative area of α-cells (P ≤ 0.05), lower insulin content (P ≤ 0.05), increased nitric oxide and malondialdehyde concentrations, and decreased superoxide dismutase concentration (P ≤ 0.05, respectively). With time these changes became increasingly unmarked.CONCLUSIONCatch-up growth in different stages and forms induces varying degrees of islet dysfunction, possibly by corresponding changes in general physiologic parameters, pancreatic morphometry, insulin content, and the state of chronic oxidative stress.