Medial prefrontal cortex lesions abolish contextual control of competing responses
Medial prefrontal cortex lesions abolish contextual control of competing responses
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DOI：
10.1901/jeab.2005.81-04
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发表时间：
2005-11-01
影响因子：
2.7
通讯作者：
Killcross, AS
中科院分区：
文献类型：
--
作者：
Haddon, JE;Killcross, AS
关于前额叶皮层不同分区的功能专门化程度和性质存在很多争议。本研究旨在探讨大鼠内侧前额叶皮层亚区损伤的影响。在两种不同的背景下，对大鼠进行了两项双视辨别任务的训练，一项是听觉，一项是视觉。在测试中，他们收到了这些培训刺激的视听化合物在灭绝的介绍。这些化合物在训练过程中决定了相同（一致试验）或不同（不一致试验）的反应。在假操作的控制，上下文线索来控制响应不一致的刺激化合物提供的冲突信息。实验一表明，这种上下文控制的反应是不明显的个别大鼠与大量的损害，包括前额叶皮层的前边缘和扣带亚区。实验2进一步分离实验1的结果，表明特定于前扣带皮层的病变足以在呈现不一致刺激化合物的早期产生缺陷，但随着呈现的进展，性能未受损。这种早期赤字表明前扣带皮层在检测反应冲突中的作用，以及内侧前额叶皮层在竞争反应的上下文控制中的作用，为大鼠前额叶皮层内的功能专业化提供了证据。
There is much debate as to the extent and nature of functional specialization within the different subregions of the prefrontal cortex. The current study was undertaken to investigate the effect of damage to medial prefrontal cortex subregions in the rat. Rats were trained on two biconditional discrimination tasks, one auditory and one visual, in two different contexts. At test, they received presentations of audiovisual compounds of these training stimuli in extinction. These compounds had dictated either the same (congruent trials) or different (incongruent trials) responses during training. In sham-operated controls, contextual cues came to control responding to conflicting information provided by incongruent stimulus compounds. Experiment I demonstrated that this contextual control of responding was not evident in individual rats with large amounts of damage that included the prelimbic and cingulate subregions of the prefrontal cortex. Experiment 2 further dissociated the result of Experiment 1, demonstrating that lesions specific to the anterior cingulate cortex were sufficient to produce a deficit early on during presentation of an incongruent stimulus compound but that performance was unimpaired as presentation progressed. This early deficit suggests a role for the anterior cingulate cortex in the detection of response conflict, and for the medial prefrontal cortex in the contextual control of competing responses, providing evidence for functional specialization within the rat prefrontal cortex.