Researches on pyrimidines. CIII. The discovery of 5-methyl-cytosine in tuberculinic acid, the nucleic acid of the tubercle bacillus
Researches on pyrimidines. CIII. The discovery of 5-methyl-cytosine in tuberculinic acid, the nucleic acid of the tubercle bacillus
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DOI：
10.1021/ja01688a030
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发表时间：
1925-01-01
影响因子：
15
通讯作者：
Coghill, RD
中科院分区：
文献类型：
--
作者：
Johnson, TB;Coghill, RD
对于对动物和植物细胞有机体的生命过程感兴趣的有机化学家来说，最感兴趣和最重要的问题是那些涉及更准确地确定和定义细胞基本的、建设性成分的组成和分子结构的问题。细胞有机体的生物发育取决于活细胞中功能特征有机组合的相互作用，其生长过程中发生的正常生命变化只是化学结构深刻且渐进的变化的揭示。在自然界中存在的多种形式的细菌细胞中，包含致病类型并作为人类敌人的细菌细胞群值得首先考虑。幸运的是，结核杆菌可能比该类群的任何其他代表都受到更多关注，它是一种现在可以轻松大量获得的生物体，从而可用于精确的化学研究。由于这种病原生物的人工培养取得了进展，并且在国家结核病协会研究委员会的协助下，我们才有可能获得有趣的化学结果，我们现在在本文中报告这些结果。致病性和非致病性生物体之间是否存在结构差异，以及这些差异是否可以通过应用化学研究方法检测到，这些问题非常重要，并将在研究过程中受到关注。
The problems of the greatest interest and importance to the organic chemist who is interested in the life processes of animal and plant cellular organisms are those dealing with a more accurate determination and definition of the composition and molecular structure of the fundamental, constructive constituents of the cell. The biological development of cellular organisms is dependent upon the interaction of characteristic organic combinations functioning in the living cell, and the normal life changes taking place during its growth are only revelations of profound and progressive alterations in chemical structures. Of the many forms of bacterial cells which havebeen shown to exist in nature, that group which embraces the pathogenic type and operates as an enemy to mankind deserves the first consideration. Fortunately, the tubercle bacillus, which has probably received more attention than any other representative of this group, is an organism which can now be ob-'tained easily in large quantity and thereby made available for accurate chemical research. Due to the progress that has been made in the artificial cultivation of this pathogenic organism, andthrough the assistance of the Research Committee of the National Tuberculosis Association, it has been made possible for us to obtain the interesting chemical results which we now report in this paper. The questions whether any consti-tutional differences exist between pathogenic and non-pathogenic organisms and whether such differences are detectable by application of the chemical method of research, are important ones and will receive attention during