Diabetic Cardiovascular Disease Induced by Oxidative Stress.
Diabetic Cardiovascular Disease Induced by Oxidative Stress.
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DOI：
10.3390/ijms161025234
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发表时间：
2015-10-23
影响因子：
5.6
通讯作者：
Tsao PS
中科院分区：
文献类型：
--
作者：
Kayama Y;Raaz U;Jagger A;Adam M;Schellinger IN;Sakamoto M;Suzuki H;Toyama K;Spin JM;Tsao PS
心血管疾病（CVD）是糖尿病（DM）患者发病和死亡的主要原因。糖尿病可导致多种心血管并发症，包括冠状动脉疾病（CAD）、心脏肥大和心力衰竭（HF）。HF是DM患者最常见的死亡原因之一，由DM诱导的CAD和糖尿病心肌病引起。氧化应激与糖尿病的发病机制密切相关，是由活性氧（ROS）过度产生引起的。ROS过度产生与高血糖症和代谢紊乱相关，例如抗氧化功能受损以及抗氧化活性受损。DM患者长期暴露于氧化应激可诱导一系列组织中的慢性炎症和纤维化，导致这些组织中疾病状态的形成和进展。事实上，氧化应激标志物在糖尿病患者中过表达，表明ROS增加可能是糖尿病并发症发生的主要原因。因此，了解氧化应激介导的病理生理机制对于预防和治疗糖尿病诱导的CVD至关重要。目前的审查重点是糖尿病引起的心血管疾病和氧化应激之间的关系，同时强调从糖尿病心脏和血管疾病的研究结果对这种关系的最新见解。
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among patients with diabetes mellitus (DM). DM can lead to multiple cardiovascular complications, including coronary artery disease (CAD), cardiac hypertrophy, and heart failure (HF). HF represents one of the most common causes of death in patients with DM and results from DM-induced CAD and diabetic cardiomyopathy. Oxidative stress is closely associated with the pathogenesis of DM and results from overproduction of reactive oxygen species (ROS). ROS overproduction is associated with hyperglycemia and metabolic disorders, such as impaired antioxidant function in conjunction with impaired antioxidant activity. Long-term exposure to oxidative stress in DM induces chronic inflammation and fibrosis in a range of tissues, leading to formation and progression of disease states in these tissues. Indeed, markers for oxidative stress are overexpressed in patients with DM, suggesting that increased ROS may be primarily responsible for the development of diabetic complications. Therefore, an understanding of the pathophysiological mechanisms mediated by oxidative stress is crucial to the prevention and treatment of diabetes-induced CVD. The current review focuses on the relationship between diabetes-induced CVD and oxidative stress, while highlighting the latest insights into this relationship from findings on diabetic heart and vascular disease.