Blunted neural response to emotional faces in the fusiform and superior temporal gyrus may be marker of emotion recognition deficits in pediatric epilepsy.
Blunted neural response to emotional faces in the fusiform and superior temporal gyrus may be marker of emotion recognition deficits in pediatric epilepsy.
复制标题
DOI：
10.1016/j.yebeh.2020.107432
复制
发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Nelson EE
中科院分区：
文献类型：
--
作者：
Morningstar M;Hung A;Grannis C;French RC;Mattson WI;Ostendorf AP;Gedela S;Englot DJ;Nelson EE
癫痫患者有社会认知缺陷的风险，包括识别非语言情感线索的能力障碍(即情感识别[ER]技能)。这种缺陷在儿童期发作的成年患者中尤其明显，在患有癫痫的儿童和青少年中已经很明显。尽管这些损害与成年患者对面部情绪信息的迟钝神经反应有关，但对青年癫痫患者ER缺陷的神经相关性知之甚少。目前的研究比较了在功能性磁共振成像(FMRI)中，患有顽固性局灶性癫痫的年轻人和典型的发育中的年轻人的ER准确性和对情绪面孔的神经反应。与正常发育的受试者相比，癫痫患者表现出a)ER任务的准确性降低，b)双侧梭形回和右侧颞上回(STG)对情绪面孔(与中性面孔相比)反应迟钝。这些区域的激活与表现相关，这表明这些面孔反应区域内的异常反应可能在内质网损伤中发挥功能作用。与处理社会情绪线索相关的神经回路的参与减少可能是患有局灶性癫痫的青少年社会认知缺陷的风险标志。
Individuals with epilepsy are at risk for social cognition deficits, including impairments in the ability to recognize nonverbal cues of emotion (i.e., emotion recognition [ER] skills). Such deficits are particularly pronounced in adult patients with childhood-onset seizures and are already evident in children and adolescents with epilepsy. Though these impairments have been linked to blunted neural response to emotional information in faces in adult patients, little is known about the neural correlates of ER deficits in youth with epilepsy. The current study compared ER accuracy and neural response to emotional faces during functional magnetic resonance imaging (fMRI) in youth with intractable focal epilepsy and typically developing youth. Relative to typically developing participants, individuals with epilepsy showed a) reduced accuracy in the ER task and b) blunted response to emotional faces (vs. neutral faces) in the bilateral fusiform gyri and right superior temporal gyrus (STG). Activation in these regions was correlated with performance, suggesting that aberrant response within these face-responsive regions may play a functional role in ER impairments. Reduced engagement of neural circuits relevant to processing socioemotional cues may be markers of risk for social cognitive deficits in youth with focal epilepsy.
登录
查看更多内容
影响因子：
2.4
作者：
Hennion, Sophie;Delbeuck, Xavier;Szurhaj, William
通讯作者：
Szurhaj, William
影响因子：
5.7
作者：
Dolan, RJ;Fletcher, P;Frith, CD
通讯作者：
Frith, CD
DOI：
10.1073/pnas.0800489105
发表时间：
2008-04-08
影响因子：
11.1
作者：
Hadj-Bouziane, Fadila;Bell, Andrew H.;Tootell, Roger B. H.
通讯作者：
Tootell, Roger B. H.
影响因子：
4.3
作者：
Drewel, Elena Harlan;Caplan, Rochelle
通讯作者：
Caplan, Rochelle
影响因子：
2.6
作者：
Habel, Ute;Windischberger, Christian;Moser, Ewald
通讯作者：
Moser, Ewald