Chromatic Coding from Cone-type Unselective Circuits in the Mouse Retina
Chromatic Coding from Cone-type Unselective Circuits in the Mouse Retina
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DOI：
10.1016/j.neuron.2012.12.012
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发表时间：
2013-02-06
期刊：
影响因子：
16.2
通讯作者：
Euler, Thomas
中科院分区：
文献类型：
--
作者：
Chang, Le;Breuninger, Tobias;Euler, Thomas
视网膜专业化，如锥光感受器视蛋白表达梯度，发现在几种脊椎动物物种，直观地认为是有害的色觉。在小鼠中，大多数视锥细胞共表达“蓝色”和“绿色”视蛋白。共表达比率沿着背腹轴变化，导致“绿色”占主导地位的背侧和“蓝色”占主导地位的腹侧视网膜。在这里，我们想知道这些特化是如何影响色彩处理的，特别是关于视蛋白过渡区，视蛋白共表达从“绿色”转变为“蓝色”的带。“使用电生理学，建模和钙成像，我们发现“α样”视网膜神经节细胞，以前没有涉及色彩处理，当位于视蛋白过渡区附近时，显示颜色对手反应。此外，方向选择性神经节细胞在这个区域内的颜色序列的差异。我们的数据表明，背腹侧视蛋白分布，结合传统的时空处理，使小鼠神经节细胞反应颜色对手，而不需要锥型选择性连接。
Retinal specializations such as cone-photoreceptor opsin-expression gradients, as found in several vertebrate species, are intuitively considered detrimental to color vision. In mice, the majority of cones coexpress both "blue" and "green" opsin. The coexpression ratio changes along the dorsoventral axis, resulting in a "green"-dominant dorsal and a "blue"-dominant ventral retina. Here, we asked how these specializations affect chromatic processing, especially with respect to the opsin transitional zone, the band where opsin coexpression shifts from "green" to "blue." Using electrophysiology, modeling, and calcium imaging, we found that "alpha-like" retinal ganglion cells, which previously have not been implicated in chromatic processing, display color-opponent responses when located in the vicinity of the opsin transitional zone. Moreover, direction-selective ganglion cells within this zone respond differentially to color sequences. Our data suggest that the dorsoventral opsin distribution, in combination with conventional spatiotemporal processing, renders mouse ganglion cell responses color-opponent without requiring cone-type selective connectivity.