MYB and MYC in the cell cycle.
MYB and MYC in the cell cycle.
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DOI：
10.1101/sqb.1991.056.01.014
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
J. Bishop;Martin Eilers;A. Katzen;Thomas B. Kornberg;G. Ramsay;S. Schirm
中科院分区：
文献类型：
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作者：
J. Bishop;Martin Eilers;A. Katzen;Thomas B. Kornberg;G. Ramsay;S. Schirm
驱动哺乳动物细胞分裂的引擎至少有三种方式。首先，有信号通路作为加速器，在发动机空转时激活发动机，并在细胞分裂需要时保持其运行。原癌基因编码的蛋白质代表这些途径的组成部分，从生长因子及其受体到对有丝分裂刺激反应而激活的转录因子(Bishop 1991a)。其次，当细胞应该停止分裂时，多个调控器会延缓或停止发动机。肿瘤抑制基因的产物可能是州长的候选人，尽管它们的作用机制目前尚不清楚(马歇尔1991)。第三，引擎按照严格的时间表运行，由生化时钟或振荡器维持，围绕CDC2激酶和周期蛋白构建(护士1990)。原癌基因myb和myc是细胞周期的潜在加速器(L/ischer和艾森曼1990a，b)。这两个基因首先在逆转录病毒中作为癌基因出现。这两个都是小基因家族的原型，这些基因家族的大小尚不确定，其中大多数成员的研究仍然很少。两者都编码具有短半衰期的核磷蛋白，结合DNA中的特定位点，并可能作为转录因子的组成部分。两者都被不同形式的证据牵连为细胞增殖的积极影响因素(有关综述，见Liischer和Eisenman 1990a，b；也见Mucenski等人)。1991年)。在这里，我们总结了我们的努力，以表征MYB和MYC蛋白的生化特性，并探索这些蛋白在细胞周期中的作用。
The engine that drives mammalian cell division is governed in at least three ways. First, there are signaling pathways that serve as accelerators to activate the engine when it is idling and keep it running as long as cell division is required. The proteins encoded by proto-oncogenes represent components of these pathways, ranging from growth factors and their receptors to transcription factors that are activated in response to mitogenic stimuli (Bishop 1991a). Second, multiple governors retard or arrest the engine when the cell should cease division. The products of tumor suppressor genes are likely candidates for governors, although their mechanisms of action are presently obscure (Marshall 1991). Third, the engine runs according to a strict schedule that is maintained by a biochemical clock or oscillator, constructed around the cdc2 kinase and the cyclins (Nurse 1990).The proto-oncogenes MYB and MYC exemplify potential accelerators for the cell cycle (L/ischer and Eisenman 1990a, b). Both genes were encountered first as oncogenes in retroviruses. Both are prototypes for small gene families whose sizes are not yet certain and most of whose members remain poorly studied. Both encode nuclear phosphoproteins that have short halflives, bind specific sites in DNA, and probably function as components of transcription factors. Both have been implicated by diverse forms of evidence as positive effectors of cellular proliferation (for review, see Liischer and Eisenman 1990a, b; see also Mucenski et al. 1991). Here we summarize our efforts to characterize the biochemical properties of the MYB and MYC proteins and to explore the role of these proteins in the cell cycle.